Filed (PHiled). Greater than 1-2 years since publication

Management of refractory chylothorax in the neonatal intensive care unit: A 22-year experience

Yoshiaki Takahashi, Yoshiaki Kinoshita, Takashi Kobayashi, Yuhki Arai, Toshiyuki Ohyama, Naoki Yokota, Koichi Saito, Yu Sugai, Shoichi TakanoNiigata University Graduate School of Medical and Dental SciencesJapan Pediatric InternationalPediatr Int 2022; 64: DOI: 10.1111/ped.15043 AbstractBackground: The aim was to assess the therapeutic strategy of patients with chylothorax in a neonatal intensive care unit.Methods: Twenty-eight infants with chylothorax were included […]

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Lymphatic anomalies during lifetime in patients with Noonan syndrome: Retrospective cohort study

Jessie W. Swarts, Lotte E. R. Kleimeier, Erika K. S. M. Leenders, Tuula Rinne, Willemijn M. Klein, Jos M. T. DraaismaAmalia Children’s Hospital, Radboud Institute for Health Sciences and Radboud University Medical CenterNetherlands American Journal of Medical Genetics AAm J Med Genet A 2022; 188: 3242-3261DOI: 10.1002/ajmg.a.62955 AbstractNoonan syndrome (NS) has been associated with an increased

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Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema

Alicia B. Byrne, Pascal Brouillard, Drew L. Sutton, Jan Kazenwadel, Saba Montazaribarforoushi, Genevieve A. Secker, Anna Oszmiana, Milena Babic, Kelly L. Betterman, Peter J. Brautigan, Melissa White, Sandra G. Piltz, Paul Q. Thomas, Christopher N. Hahn, Matthias Rath, Ute Felbor, G. Christoph Korenke, Christopher L. Smith, Kathleen H. Wood, Sarah E. Sheppard, Denise M. Adams,

Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema Read More »

MR lymphangiography of lymphatic abnormalities in children and adults with Noonan syndrome

C. C. Pieper, J. Wagenpfeil, A. Henkel, S. Geiger, T. Köster, K. Hoss, J. A. Luetkens, C. Hart, U. I. Attenberger, A. MüllerUniversity of Bonn and Children’s Hospital.Germany Scientific ReportsSci Rep 2022; 12: DOI: 10.1038/s41598-022-13806-w AbstractNoonan syndrome is associated with complex lymphatic abnormalities. We report dynamic-contrast enhanced MR lymphangiography (DCMRL) findings in children and adults with

MR lymphangiography of lymphatic abnormalities in children and adults with Noonan syndrome Read More »

Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy

Lotte E. R. Kleimeier, Carolinevan Schaik, Erika Leenders, Maxim Itkin, Willemijn M. Klein, Jos M. T. DraaismaRadboudumc Amalia Children’s Hospital and Radboud University Medical Center. University of Pennsylvania.Netherlands and United States Journal of Clinical MedicineJ Clin Med 2022; 11: DOI: 10.3390/jcm11113128 AbstractDysregulation of the Ras/Mitogen-activated protein kinase (MAPK) signaling pathway is suggested to play a pivotal

Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy Read More »

Lymphatic Abnormalities in Noonan Syndrome Spectrum Disorders: A Systematic Review

Julia Sleutjes, Lotte Kleimeier, Erika Leenders, Willemijn Klein, Jos DraaismaRadboud University Medical Center and Amalia Children’s Hospital.Netherlands Molecular SyndromologyMol Syndromol 2022; DOI: 10.1159/000517605 AbstractNoonan syndrome spectrum disorders are a group of phenotypically related conditions, resembling Noonan syndrome, caused by germline pathogenic variants in genes within the Ras/mitogen-activated protein kinase (Ras/MAPK) signalling pathway. Lymphatic dysplasia with a

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Lymphatic anomalies in congenital heart disease

Karen I. Ramirez-Suarez, Luis Octavio Tierradentro-Garcia, David M. Biko, Hansel J. Otero, Ammie M. White, Yoav Dori, Christopher L. Smith, Seth Vatsky, Jordan B. RappChildren’s Hospital of Philadelphia and University of Pennsylvania.United States Pediatric RadiologyPediatr Radiol 2022; 52: 1862-1876DOI: 10.1007/s00247-022-05449-w AbstractCongenital heart disease can lead to various lymphatic complications including traumatic leaks, lymphatic overproduction, conduction abnormalities

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Neonatal lymphatic flow disorders: central lymphatic flow disorder and isolated chylothorax, diagnosis and treatment using novel lymphatic imaging and interventions technique

Deborah Rabinowitz, Kevin Dysart, Maxim ItkinNemours Children’s Hospital. Sidney Kimmel Medical College at Thomas Jefferson University. Perelman School of Medicine at the University of Pennsylvania. United States Current Opinion in PediatricsCurr Opin Pediatr 2022; 34: 191-196DOI: 10.1097/MOP.0000000000001109 AbstractPurpose of review: Neonatal lymphatic disorders (NLDs) are conditions that are relatively rare and difficult to treat. The recent development

Neonatal lymphatic flow disorders: central lymphatic flow disorder and isolated chylothorax, diagnosis and treatment using novel lymphatic imaging and interventions technique Read More »

Management of congenital and postoperative chylothorax: Use of thoracoscopic lymphatic leak ligations with intraoperative ICG lymphangiography

Shunya Takada, Chiyoe Sirota, Hiroo Uchida, Hizuru Amano, Akinari Hinoki, Wataru Sumida, Satoshi Makita, Masamune Okamoto, Aitaro, Takimoto, Akihiro Yasui, Youichi Nakagawa, Daiki Kato, Yaohui Guo, Takahisa TainakaNagoya University Graduate School of Medicine. Japan Journal of Pediatric SurgeryJ Pediatr Surg 2022; DOI: 10.1016/j.jpedsurg.2022.11.018 AbstractBackground: Congenital chylothorax (CCT) and postoperative chylothorax (POCT) are rare and difficult to treat.

Management of congenital and postoperative chylothorax: Use of thoracoscopic lymphatic leak ligations with intraoperative ICG lymphangiography Read More »

Treatment and outcomes of chylothorax in children: 20-year experience of a single institute

Kanokpan Ruangnapa, Wanaporn Anuntaseree, Kantara Saelim, Pharsai Prasertsan, Maneerat Puwanant, Supaporn DissanevatePrince of Songkla UniversityThailand Journal of Thoracic DiseaseJ Thorac Dis 2022; 14: 3719-3726DOI: 10.21037/jtd-22-474 AbstractBackground: Chylothorax is an uncommon cause of pleural effusion in children. This study aimed to determine the characteristics, treatment strategies, and outcomes of chylothorax in children from a single institute.Methods: The 65 episodes

Treatment and outcomes of chylothorax in children: 20-year experience of a single institute Read More »

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