Filed (PHiled). Greater than 1-2 years since publication

Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension

Hui Zhang, Angelo D’Alessandro, Min Li, Julie A. Reisz, Suzette Riddle, Akshay Muralidhar, Todd Bull, Lan Zhao, Evgenia Gerasimovskaya, Kurt R. StenmarkUniversity of Colorado School of Medicine.  Imperial College London. United States and United Kingdom Vascular PharmacologyVasc Pharmacol 2023; 149: DOI: 10.1016/j.vph.2023.107157 AbstractRationale: Sildenafil, a well-known vasodilator known to interfere with purinergic signaling through effects on cGMP, […]

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Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertension after C75 treatment

Cuilan Hou, Lijian Xie, Tingxia Wang, Junmin Zheng, Yuqi Zhao, Qingzhu Qiu, Yi Yang, Tingting XiaoShanghai Children’s Hospital and Shanghai Jiao Tong University. NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology. Jin Shan Hospital and Fudan University. The Children’s Hospital and Zhejiang University School of Medicine. China BioMed Central Pulmonary MedicineBMC Pulm Med

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Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model

R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R.

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Outcomes of and factors associated with the development of bronchopulmonary dysplasia with pulmonary hypertension in very low birth weight infants: A retrospective study in a medical center

Han-Pi Chang, Reyin Lien, Shih-Ming Chu, Jainn-Jim Lin, Ming-Chou ChiangChang Gung Memorial Hospital and Chang Gung University College of Medicine. New Taipei Municipal TuCheng Hospital. Taiwan Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1055439 AbstractIntroduction: Bronchopulmonary dysplasia (BPD) with pulmonary hypertension (PH) leads to increased morbidity and mortality in extremely preterm infants. Recent studies have analyzed factors

Outcomes of and factors associated with the development of bronchopulmonary dysplasia with pulmonary hypertension in very low birth weight infants: A retrospective study in a medical center Read More »

Multiomics endotyping of preterm infants with bronchopulmonary dysplasia and pulmonary hypertension-A pilot study

Roopa Siddaiah, Christiana Oji‐Mmuo, Vincent P. R. Aluquin, Yuka Imamura Kawasawa, Ann Donnelly, Dustin Rousselle, Nathalie Fuentes, Eric D. Austin, Patricia SilveyraPenn State Health and Children’s Hospital. Indiana University School of Public Health. Vanderbilt University.United States Pulmonary CirculationPulm Circ 2023; 13: DOI: 10.1002/pul2.12232 Abstract Pulmonary hypertension associated with bronchopulmonary dysplasia is a severe complication of preterm

Multiomics endotyping of preterm infants with bronchopulmonary dysplasia and pulmonary hypertension-A pilot study Read More »

RASA3 is a candidate gene in sickle cell disease-associated pulmonary hypertension and pulmonary arterial hypertension

Clare C. Prohaska, Xu Zhang, Tae‐Hwi L. Schwantes‐An, Robert S. Stearman, Stanley Hooker, Rick A. Kittles, Micheala A. Aldred, Katie A. Lutz, Michael W. Pauciulo, William C. Nichols, Ankit A. Desai, Victor R. Gordeuk, Roberto F. MachadoIndiana University. University of Illinois at Chicago. City of Hope. Morehouse School of Medicine. Cincinnati Children’s Hospital Medical Center

RASA3 is a candidate gene in sickle cell disease-associated pulmonary hypertension and pulmonary arterial hypertension Read More »

Congenital Portosystemic Shunts in Children: Associations, Complications, and Outcomes

Frank DiPaola, Andrew T. Trout, Ashley E. Walther, Anita Gupta, Rachel Sheridan, Kathleen M. Campbell, Greg Tiao, Jorge A. Bezerra, Kevin E. Bove, Manish Patel, Jaimie D. NathanC.S. Mott Children’s Hospital. Cincinnati Children’s Hospital Medical Center. University of Cincinnati Medical Center. Children’s Hospital Los Angeles.United States Digestive Diseases and SciencesDig Dis Sci 2020; 65: 1239-1251DOI: 10.1007/s10620-019-05834-w

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Pulmonary Hypertension in Infants and Children with Vein of Galen Malformation and Association with Clinical Outcomes

Jai Khurana, Darren B. Orbach, Kimberlee Gauvreau, Shane A. Collins, Joseph B. Tella, Pankai B. Agrawal, Helen A. Christou, Mary P. MullenBoston Children’s Hospital, Boston. Harvard Medical School. Brigham & Women’s Hospital.United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113404 AbstractObjective: To assess the extent and resolution of pulmonary hypertension (PH), cardiovascular factors, and echocardiographic findings associated

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Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future

Candice D. Fike, Judy L. AschnerUniversity of Utah Health. Joseph M. Sanzari Children’s Hospital at Hackensack University.United States PharmaceuticalsPharmaceuticals 2023; 16: DOI: 10.3390/ph16040503 AbstractApproximately 8-42% of premature infants with chronic lung disease of prematurity, bronchopulmonary dysplasia (BPD), develop pulmonary hypertension (PH). Infants with BPD-PH carry alarmingly high mortality rates of up to 47%. Effective PH-targeted pharmacotherapies

Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future Read More »

Pulmonary Hypertension and Necrotizing Enterocolitis in Neonates Treated with Diazoxide

Mounya Duggal, Shiran S. Moore, Jessica Simoneau, Gabrielle Girard, Irene B. Gernet, Julia E. Von Oettingen, GuilhermeSant’Anna, Gabriel AltitMcGill University and Montreal Children’s Hospital. Canada American Journal of PerinatologyAm J Perinatol 2023; DOI: 10.1055/s-0043-1764385 AbstractObjective: This study aimed to evaluate the prevalence of adverse outcomes, specifically pulmonary hypertension (PH) and suspected or confirmed necrotizing enterocolitis (NEC), and

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