Filed (PHiled). Greater than 1-2 years since publication

Hemodynamic assessment of transitioning from parenteral prostacyclin to selexipag in pediatric pulmonary hypertension

Elizabeth Colglazier, Leah Stevens, Claire Parker, Hythem M. Nawaytou, Elena K. Amin, Jasmine Becerra, Martina Steurer, Jeffrey R. FinemanUniversity of California San FranciscoUnited States Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12159 AbstractDespite the increase in therapeutic options, parenteral prostacyclins remain the cornerstone in the medical management of pulmonary arterial hypertension (PAH). While the use of parenteral […]

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Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network

Stephanie S. Handler, Nidhy P. Varghese, Erika B. Rosenzweig, Delphine Yung, Usha Krishnan, Elise Whalen, Angela Bates, Catherine M. Avitabile, Emma O. Jackson, Russel Hirsch, Jeffrey Fineman, Steven H. Abman The Pediatric Pulmonary Hypertension Network (PPHNet)United States and Canada Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12031 AbstractPediatric pulmonary hypertension (PH) is a severe, life-threatening disease associated

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An emerging phenotype of pulmonary arterial hypertension patients carrying SOX17 variants

David Montani, Benoit Lechartier, Barbara Girerd, Mélanie Eyries, Maria-Rosa Ghigna, Laurent Savale, Xavier Jaïs, Andrei Seferian, Mitja Jevnikar, Athénais Boucly, Marianne Riou, Julie Traclet, Ari Chaouat, Maryline Levy, Jerome LePavec, Elie Fadel, Frédéric Perros, Florent Soubrier, Martine Remy-Jardin, Olivier Sitbon, Damien Bonnet, Marc HumbertHôpitaux de Paris, Université Paris-Saclay, Hôpital Marie Lannelongue, Hôpital Pitié-Salpêtrière, Nouvel Hôpital

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Multifactorial pulmonary hypertension in infantile scimitar syndrome

Damien Bonnet, Isabelle Szezepanski, Christophe Delacourt, Sophie Malkezadeh-Milani, Maryline LévyHôpital Necker-Enfants Malades, AP-HP, Université de ParisFrance Archives of Cardiovascular DiseaseArch Cardiovasc Dis 2022; 115: 142-150DOI: 10.1016/j.acvd.2022.01.004 AbstractBackground: Pulmonary hypertension in infantile scimitar syndrome is highly prevalent at diagnosis, and has a multifactorial origin.Aims: To analyse the constellation of anatomical anomalies and initial physiology, and their contribution to

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Respiratory viruses and postoperative hemodynamics in patients with unrestrictive congenital cardiac communications: a prospective cohort study

Kelly C. O. Abud, Clarisse M. Machado, Lucy S. Vilas Boas, Nair Y. Maeda, Eloisa S. Carvalho, Maria Francilene S. Souza, Paula V. Gaiolla, Claudia R. P. Castro1 Juliana Pereira, Marlene Rabinovitch, Antonio Augusto LopesUniversity of São Paulo School of Medicine, Pró-Sangue Foundation, Stanford University School of MedicineBrazil and United States European Journal of Medical

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Pulmonary-to-Systemic Arterial Shunt to treat Children with Severe Pulmonary Hypertension

R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, MD, Scott E. Fletcher, Russel Hirsch, Tilman Humpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien BonnetWashington University, A.N. Bakoulev

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Prematurity and Pulmonary Vein Stenosis: The Role of Parenchymal Lung Disease and Pulmonary Vascular Disease

Shilpa Vyas-Read, Nidhy P. Varghese, Divya Suthar, Carl Backes, Satyan Lakshminrusimha, Christopher J. Petit, Philip T. LevyEmory University and Children’s Healthcare of Atlanta. Baylor College of Medicine and Texas Children’s Hospital. Ohio State University and Nationwide Children’s Hospital. University of California Davis. Harvard University and Boston Children’s Hospital.United States Children (Basel)Children 2022; 9: DOI: 10.3390/children9050713 AbstractPulmonary

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Systemic Sirolimus Therapy for Infants and Children With Pulmonary Vein Stenosis

Jay D. Patel, Michael Briones, Mansi Mandhani, Shannon Jones, Divya Suthar, Rosemary Gray, Joelle Pettus, Courtney McCraken, Amanda Thomas, Christopher J. PetitEmory University and Children’s Healthcare of AtlantaUnited States Journal of the American College of CardiologyJ Am Coll Cardiol 2021; 77: 2807-2818DOI: 10.1016/j.jacc.2021.04.013 AbstractBackground: Anatomic interventions for pulmonary vein stenosis (PVS) in infants and children have been

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The vascular phenotype of BPD: new basic science insights-new precision medicine approaches

Wojciech Durlak, Bernard ThébaudUniversity of Ottawa. Jagiellonian University Medical College. Poland and Canada Pediatric ResearchPediatr Res 2022; DOI: 10.1038/s41390-022-02428-7 AbstractBronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Up to 1/3 of children with BPD develop pulmonary hypertension (PH). PH increases mortality, the risk of adverse neurodevelopmental outcome and lacks effective treatment. Current vasodilator

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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target

Stephen L. Archer, Glenn Marsboom, Gene H. Kim, Hannah J. Zang, Peter T. Toth, Eric C. Svensson, Jason R. B. Dyke, Mardi Gomberg-Maitland, Bernard Thébaud, Aliya N. Husain, Nicole Cipriani, Jalees RehmaneUniversity of Chicago. University of Alberta.United States and Canada CirculationCirculation 2010; 121: 2661-2671DOI: 10.1161/CIRCULATIONAHA.109.916098 AbstractBackground: Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle

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