Filed (PHiled). Greater than 1-2 years since publication

G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Charifa Awada, Alice Bourgeois, Sara-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jevaseelan, Steeve ProvencherCentre de recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec. Janssen Research and Development. Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2023; DOI: 10.1165/rcmb.2022-0300OC AbstractPulmonary […]

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Quantitative Assessment of Regional Pulmonary Transit Times in Pulmonary Hypertension

Jackson E, Moore, John W. Cerne, Ashitha Pathrose, Manik Veer, Roberto Sarnari, Ann Ragin, James C. Carr, Michael MarklNorthwestern UniversityUnited States Journal of Magnetic Resonance ImagingJ Magnet Reson Imag 2023; 57:727-737DOI: 10.1002/jmri.28343 AbstractBackground: Pulmonary hypertension (PH) contributes to restricted flow through the pulmonary circulation characterized by elevated mean pulmonary artery pressure acquired from invasive right heart catheterization

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BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension

Iona Cuthbertson, Nicholas W. Morrel, Paola CarusoUniversity of Cambridge School of Clinical MedicineUnited Kingdom Circulation ResearchCirc Res 2023; 132(1):109-126DOI: 10.1161/CIRCRESAHA.122.321554 AbstractPulmonary arterial hypertension forms the first and most severe of the 5 categories of pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of peripheral pulmonary arteries, caused by the excessive proliferation of vascular wall cells,

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Pulmonary hypertension due to high cardiac output

Kanza N. Qaiser, Sandeep Sahay, Arriano R. TonelliCleveland Clinic. Houston Methodist Hospital.United States Respiratory MedicineRespir Med 2023; DOI: 10.1016/j.rmed.2022.107034 AbstractPulmonary hypertension (PH) is usually associated with a normal or decreased cardiac output (CO). Less commonly, PH can occur in the context of a hyperdynamic circulation, characterized by high CO (>8 L/min) and/or cardiac index ≥4 L/min/m2 in

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Right ventriculo-pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension

Toshitaka Nakaya, Hiroshi Ohira, Takahiro Sato, Taku Watanabe, Masaharu Nishimura, Noriko Oyama-Manabe, Masaru Kato, Yoichi M. Ito and Ichizo TsujinoHokkaido University Hospital. The Institute of Statistical Mathematics.Japan Pulmonary CirculationPulm Circ 2020; 10: DOI: 10.1177/2045894020957223 AbstractRight ventricular function critically affects the prognosis of patients with pulmonary arterial hypertension. We aimed to analyze the prognostic value of right

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Sotatercept for the Treatment of Pulmonary Arterial Hypertension

Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Jennifer Barnes, Peter G. Linde, Janethe de Oliveira Pena, David B. BadeschPULSAR Trial Investigators.France, United States, United Kingdom,

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Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension

Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias1, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Janethe de Oliveira Pena, David B. BadeschHôpital Bicêtre, Assistance Publique-Hôpitaux de Paris. University of Michigan Health System. Imperial

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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Paul J. Critser, Nara S. Higano, Jean A. Tkach, Emilia S. Olson, David R. Spielberg, Paul S. Kingma, Robert J, Fleck, Sean M. Lang, Ryan A. Moore, Michael D. Taylor, Jason C. WoodsUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Baylor College of Medicine and Texas Children’s Hospital.United States American Journal of Respiratory and

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Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension

Paul J. Critser, Debra Boyer, Gary A. Visner, Shane L. Collins, Mary P. MullenHarvard University and Boston Children’s Hospital.United States Pediatric TransplantationPediatr Transplant 2022; 26: e14236DOI: 10.1111/petr.14236 AbstractBackground: Lung transplantation is a therapeutic option for end-stage pediatric pulmonary hypertension (PH). Right ventricular (RV) recovery post-lung transplant in children with PH has not been well-described, and questions persist

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Echocardiography-derived septal curvature correlated with invasive hemodynamics in pediatric pulmonary hypertension

Paul J. Critser, Patrick D. Evers, Kristin Schneider, Russel Hirsch, Michael D. Taylor, Jason C. Woods, Sean M. LangUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center.United States Journal of EchocardiographyJ Echocardiogr 2022; 20: 24-32DOI: 10.1007/s12574-021-00545-6 AbstractBackground: Right ventricular function and afterload are associated with clinical outcomes in pulmonary hypertension (PH). MRI-derived interventricular septal curvature has been

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