Filed (PHiled). Greater than 1-2 years since publication

Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients

Ali Ahmadi, Jennifer M. Renaud, Steven Promislow, Ian G. Burwash, Girish Dwivedi, Ran Klein, Jason G. E. Zelt, Robert A. deKamp, Rob S. Beanlands, Lisa M. MielniczukUniversity of Ottawa.Canada Journal of Nuclear CardiologyJ Nucl Cardiol 2021; 28: 2784-2795DOI: 10.1007/s12350-020-02144-x AbstractBackground: Reduced left ventricular (LV) function is associated with increased myocardial oxygen consumption rate (MVO2) and altered sympathetic […]

Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients Read More »

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

Jason G. E. Zelt, Virgilio Cadete, Yupu Deng, Rafael Godoy, Alexanne Cuillerier, Katelynn Rowe, Mohammad Abdul-Ghani, Lynn Megeney, Yan Burelle, Antonio Giulivi, Alexandre F. R. Stewart, Steeve Provencher, Sandra Breuils-Bonnet, Sébastien Bonnet, Robert deKemp, Rob Beanlands, Lisa M. Mielniczuk, Duncan J. StewartUniversity of Ottawa.Canada HypertensionHypertension 2022; 79: 2774-2786DOI: 10.1161/HYPERTENSIONAHA.122.19300 AbstractBackground: We explored the mechanism of maladaptive right

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics Read More »

Patent ductus arteriosus and the risk of bronchopulmonary dysplasia-associated pulmonary hypertension

Hythem Nawaytou, Nancy K. Hills, Ronald I. ClymanUniversity of California San Francisco.United States Pediatric ResearchPediatr Res 2023; DOI: 10.1038/s41390-023-02522-4 AbstractBackground: The aim of the study was to determine whether prolonged exposure to a moderate/large patent ductus arteriosus left-to-right shunt (PDA) increases the risk of late (beyond 36 weeks) pulmonary hypertension (BPD-PH) and pulmonary vascular disease (BPD-PVD) during

Patent ductus arteriosus and the risk of bronchopulmonary dysplasia-associated pulmonary hypertension Read More »

Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience

David Edward Youssef, Stephanie S. Handler, Susan Marjorie Richards, Catherine Anne Sheppard, Jenna Smith, Kathryn Tillman, Matthew Pietrosanu, Edward Kirkpatrick, Angela Bates University of Alberta and Stollery Children’s Hospital. Medical College of Wisconsin.Canada and United States Frontiers in PediatricsFront Pediatr 2023; DOI: 10.3389/fped.2023.1055131 AbstractIntroduction: Phosphodiesterase type 5 (PDE5) inhibitors, with sildenafil the earliest among them, are widely used

Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience Read More »

Sleep disordered breathing and its relation to stroke and pulmonary hypertension in children with sickle cell disease: a single-center cross-sectional study

Azza Tantawy, Nayera El‑Sherif, Sara Makkeyah, Nahed Salah Eldeen, Noura Bahaa El‑Din Farghal, Nanies Soliman, Fatma S. E. EbeidAin Shams University.Egypt Annals of HematologyAnn Hematol 2023; 102: 271-281DOI: 10.1007/s00277-023-05099-4 AbstractSleep disordered breathing (SDB) is a common underdiagnosed sequela of sickle cell disease (SCD) that has been linked to the frequency of vaso-occlusive crises. To determine the frequency of SDB in children with SCD and its association to SCD-related

Sleep disordered breathing and its relation to stroke and pulmonary hypertension in children with sickle cell disease: a single-center cross-sectional study Read More »

Population pharmacokinetics of riociguat in a pediatric population (aged ≥ 6 years) with pulmonary arterial hypertension

Stefan Willmann, Andrea Kerstin Keller, Michaela Meyer, Dorina van der Mey, Gagriela Wirsching, Yang Zhang, Henk-Jan Drenth, Anne Keunecke, Esmée Vendel, Soundos SalehBayer AG. LAP&P Consultants.Germany Pediatric PulmonologyPediatr Pulmonol 2023; 58: 908-917DOI: 10.1002/ppul.26277 AbstractBackground: The PATENT-CHILD study investigated riociguat in children aged ≥ 6 to <18 years with pulmonary arterial hypertension (PAH) treated with tablets or an

Population pharmacokinetics of riociguat in a pediatric population (aged ≥ 6 years) with pulmonary arterial hypertension Read More »

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen, Anton Vonk Noordegraaf, Peter ten Dijke, Rudolf A. de Boer, Harm Jan Bogaard, Marie José Goumans, Rolf M. F. BergerLeiden University Medical Center. University of Groningen and Beatrix Children’s Hospital. Vrije Universiteit Amsterdam. University of Groningen and University Medical Center Groningen.Netherlands AngiogenesisAngiogenesis 2022; 25: 99-112DOI: 10.1007/s10456-021-09812-7 AbstractPulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling Read More »

A North American, single-center experience implanting fenestrated atrial devices and atrial flow regulators into a heterogeneous group of pediatric pulmonary hypertension patients

David Edward Youssef, Konstantin Averin, Susan Richards, Catherine Sheppard, Cameron Seaman, Matthew Pietrosanu and Angela BatesUniversity of Alberta and Stollery Children’s Hospital. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.Canada and United States Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1073336 AbstractIntroduction: The clinical deterioration commonly experienced by pediatric patients with pulmonary arterial hypertension (PAH) has

A North American, single-center experience implanting fenestrated atrial devices and atrial flow regulators into a heterogeneous group of pediatric pulmonary hypertension patients Read More »

Quantifying side effects and caregiver burdens of pediatric pulmonary hypertension therapies

Erik J. Nelson, Ella Cook, Samara Nelson, Rebecca Brown, Megan Pierce, Ashley Bangerter Seelos, Heather Stickle and Michael JohansenBrigham Young University. Utah State University. Indiana University School of Medicine. United States BioMed Central PediatricsBMC Pediatr 2023; 23: DOI: 10.1186/s12887-023-03860-2 AbstractBackground and objectives: Pulmonary hypertension (PH) is a rare, but serious disease among children. However, PH has been

Quantifying side effects and caregiver burdens of pediatric pulmonary hypertension therapies Read More »

Pulmonary hypertension screening in children with sickle cell disease

Kok Hoe Chan, Syeda Hiba Rizvi, Wilfredo De Jesus-Rojas, James M. Stark, Ricardo A. Mosquera, Adrianna Carolina Prada-Ruiz, Traci Gonzalez, Deborah L. Brown, Neethu M. Menon, Trinh T. Nguyen, Cindy K. Jon, Aravind YadavUniversity of Texas Health Science Center at Houston. Ponce Health Science University and Ponce Research Institute. Baylor College of Medicine.United States Pediatric

Pulmonary hypertension screening in children with sickle cell disease Read More »

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