Diagnostic Testing for Pulmonary Vascular Disease. Non-invasive Testing

PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension

Jennifer K. Trittmann, Hanadi Almazroue, Leif D. Nelin, Terri A. Shaffer, Charanda R. Celestine, Henry W. Green, Raphael A. MalbrueOhio State University and Nationwide Children’s Hospital.United States Pediatric ResearchPediatr Res 2022; 92: 631-636DOI: 10.1038/s41390-021-01840-9 AbstractPulmonary artery acceleration time (PAT) and PAT: ejection time (PATET) ratio are echocardiographic measurements of pulmonary arterial hypertension (PAH). These noninvasive quantitative […]

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Innovations in Pediatric Therapeutics Development: Principles for the Use of Bridging Biomarkers in Pediatric Extrapolation

Thomas R. Fleming, Christine E. Garnett, Laurie S. Conklin, Solange Corriol‑Rohou, Sudharshan Hariharan, Daphne Hsu, Guenther Mueller‑Velten, Yeruk Mulugeta, Ronald Portman, Mark D. Rothmann, Norman L. Stockbridge, Simon Wandel, Jialu Zhang, Lynne YaoUniversity of Washington. U.S. Food and Drug Administration. Janssen Research and Development. AstraZeneca. Children’s Hospital at Montefiore and Albert Einstein College of Medicine. Novartis Pharma AG and Novartis Pharmaceuticals.United States Therapeutic Innovation and Regulatory ScienceTher Innov Regul Sci 2023; 57: 109-120DOI: 10.1007/s43441-022-00445-6 AbstractEven with recent substantive improvements in health care in pediatric populations, considerable need remains

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Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients

Ali Ahmadi, Jennifer M. Renaud, Steven Promislow, Ian G. Burwash, Girish Dwivedi, Ran Klein, Jason G. E. Zelt, Robert A. deKamp, Rob S. Beanlands, Lisa M. MielniczukUniversity of Ottawa.Canada Journal of Nuclear CardiologyJ Nucl Cardiol 2021; 28: 2784-2795DOI: 10.1007/s12350-020-02144-x AbstractBackground: Reduced left ventricular (LV) function is associated with increased myocardial oxygen consumption rate (MVO2) and altered sympathetic

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Pulmonary hypertension screening in children with sickle cell disease

Kok Hoe Chan, Syeda Hiba Rizvi, Wilfredo De Jesus-Rojas, James M. Stark, Ricardo A. Mosquera, Adrianna Carolina Prada-Ruiz, Traci Gonzalez, Deborah L. Brown, Neethu M. Menon, Trinh T. Nguyen, Cindy K. Jon, Aravind YadavUniversity of Texas Health Science Center at Houston. Ponce Health Science University and Ponce Research Institute. Baylor College of Medicine.United States Pediatric

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Quantitative Assessment of Regional Pulmonary Transit Times in Pulmonary Hypertension

Jackson E, Moore, John W. Cerne, Ashitha Pathrose, Manik Veer, Roberto Sarnari, Ann Ragin, James C. Carr, Michael MarklNorthwestern UniversityUnited States Journal of Magnetic Resonance ImagingJ Magnet Reson Imag 2023; 57:727-737DOI: 10.1002/jmri.28343 AbstractBackground: Pulmonary hypertension (PH) contributes to restricted flow through the pulmonary circulation characterized by elevated mean pulmonary artery pressure acquired from invasive right heart catheterization

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Right ventriculo-pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension

Toshitaka Nakaya, Hiroshi Ohira, Takahiro Sato, Taku Watanabe, Masaharu Nishimura, Noriko Oyama-Manabe, Masaru Kato, Yoichi M. Ito and Ichizo TsujinoHokkaido University Hospital. The Institute of Statistical Mathematics.Japan Pulmonary CirculationPulm Circ 2020; 10: DOI: 10.1177/2045894020957223 AbstractRight ventricular function critically affects the prognosis of patients with pulmonary arterial hypertension. We aimed to analyze the prognostic value of right

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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Paul J. Critser, Nara S. Higano, Jean A. Tkach, Emilia S. Olson, David R. Spielberg, Paul S. Kingma, Robert J, Fleck, Sean M. Lang, Ryan A. Moore, Michael D. Taylor, Jason C. WoodsUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Baylor College of Medicine and Texas Children’s Hospital.United States American Journal of Respiratory and

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Echocardiography-derived septal curvature correlated with invasive hemodynamics in pediatric pulmonary hypertension

Paul J. Critser, Patrick D. Evers, Kristin Schneider, Russel Hirsch, Michael D. Taylor, Jason C. Woods, Sean M. LangUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center.United States Journal of EchocardiographyJ Echocardiogr 2022; 20: 24-32DOI: 10.1007/s12574-021-00545-6 AbstractBackground: Right ventricular function and afterload are associated with clinical outcomes in pulmonary hypertension (PH). MRI-derived interventricular septal curvature has been

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Pulmonary hypertension in extremely preterm infants: a call to standardize echocardiographic screening and follow-up policy

Sanne Arjaans, Elvira A. H. Zwart, Marc Roofthooft, Elisabeth M. W. Kooi, Arend F. Bos, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen and University of GroningenNetherlands European Journal of PediatricsEur J Pediatr 2021; 180: 1855-1865DOI: 10.1007/s00431-021-03931-5 AbstractPulmonary hypertension (PH) is a frequent complication in extremely preterm born infants that seriously affects outcome. We

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Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management

Erika B. Rosenzweig, Steven H. Abman, Ian Adatia, Maurice Beghetti, Damien Bonnet, Sheila Haworth, D. Dunbar Ivy, Rolf M. F. BergerColumbia University and New York Presbyterian Hospital. University of Colorado and Children’s Hospital Colorado. Glenwood Children’s Heart Clinic. University Hospitals of Geneva and Lausanne. Hôpital Necker Enfants Malades, AP-HP, Université Paris Descartes. University College London.

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