Class 3. Pulmonary Hypertension Associated with Lung Disease

Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

Danielle S. Roberts, Laura G. Sherlock, Janelle N. Posey, Jamie L. Archambault, Eva S. Nozik, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus.United States Physiological ReportsPhysiol Rep 2022; 10: DOI: 10.14814/phy2.15482 AbstractSerotonin (5-hydroxytryptamine, 5-HT) is a potent pulmonary vasoconstrictor and contributes to high pulmonary vascular resistance in the developing ovine lung. In experimental pulmonary hypertension (PH), pulmonary expression of tryptophan hydroxylase-1 (TPH1), […]

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Pulmonary Hypertension in Preterm Infants Treated With Laser vs Anti-Vascular Endothelial Growth Factor Therapy for Retinopathy of Prematurity

Christopher R. Nitkin, Nicholas A. Bamat, Joanne Lagatta, Sara B. DeMauro, Henry C. Lee, Ravi Mangal Patel, Brian King, Jonathan L. Slaughter, J. Peter Campbell, Troy Richardson, Tamorah LewisUniversity of Missouri Kansas City School and Children’s Mercy Hospital. University of Pennsylvania and Children’s Hospital of Philadelphia. Medical College of Wisconsin. Stanford University. Emory University and

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Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study

Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep HarigopalNewcastle University and Royal Victoria Infirmary. United Kingdom Archives of Disease in Childhood. Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2022; 107: 13-19DOI: 10.1136/archdischild-2021-322001 AbstractObjectives: To assess the minimum incidence of life-threatening bronchopulmonary dysplasia (BPD), defined as need for positive pressure respiratory support or pulmonary vasodilators

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Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study

Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel GanzevoortUniversity of Amsterdam and Emma Children’s Hospital. University of Groningen, University Medical Center Groningen and Beatrix Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Leiden University Medical Center. Erasmus University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2022; 181: 1709-1718DOI: 10.1007/s00431-021-04355-x AbstractThe aim was

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Clinical Significance of Early Pulmonary Hypertension in Preterm Infants

Sanne Arjaans, Marian W. F. Fries, Mirthe H. Schoots, Carine F. M. Schilte, Marc T. R. Roofthooft, Elianne J. L. E. Vrijlandt, Arie F. Bos, Elisabeth M. W. Kooi, Rolf M. F. BergerUniversity of Groningen, Beatrix Children’s Hospital and University Medical Center Groningen.Netherlands Journal of PediatricsJ Pediatr 2022; 251: 74-81DOI: 10.1016/j.jpeds.2022.07.039 AbstractObjective: To characterize different phenotypes of

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Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10- to 12-week-old swine model of neonatal oxidative injury

Jarno J. Steenhorst, Alexander Hirsch, Annemarie Verzijl, Piotr Wielopolski, Daphne de Wijs-Meijler, Dirk J. Duncker, Irwin K. M. Reiss, Daphne MerkusUniversity Medical Center Rotterdam. University Clinic Munich. Munich Heart Alliance.Netherlands and Germany Journal of PhysiologyJ Physiol 2022; DOI: 10.1113/JP282906 AbstractPrematurely born young adults who experienced neonatal oxidative injury (NOI) of the lungs have increased incidence of

Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10- to 12-week-old swine model of neonatal oxidative injury Read More »

Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia with Pulmonary Hypertension

Samuel J. Gentle, Colm P. Travers, Matthew Clark, Waldemar A. Carlo, Namasivayam AmbalavanamUniversity of Alabama at Birmingham.United States American Journal of Respiratory and Critical Care MedicineAm J Respir Crit Care Med 2022; DOI: 10.1164/rccm.202203-0570OC AbstractBackground: Extremely preterm infants with evolving bronchopulmonary dysplasia (BPD) are at risk for development of BPD-associated pulmonary hypertension (BPD-PH). The presence and duration

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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Paul J. Critser, Nara S. Higano, Jean A. Tkach, Emilia S. Olson, David R. Spielberg, Paul S. Kingma, Robert J, Fleck, Sean M. Lang, Ryan A. Moore, Michael D. Taylor, Jason C. WoodsUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Baylor College of Medicine and Texas Children’s Hospital.United States American Journal of Respiratory and

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The vascular phenotype of BPD: new basic science insights-new precision medicine approaches

Wojciech Durlak, Bernard ThébaudUniversity of Ottawa. Jagiellonian University Medical College. Poland and Canada Pediatric ResearchPediatr Res 2022; DOI: 10.1038/s41390-022-02428-7 AbstractBronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Up to 1/3 of children with BPD develop pulmonary hypertension (PH). PH increases mortality, the risk of adverse neurodevelopmental outcome and lacks effective treatment. Current vasodilator

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Pulmonary hypertension in extremely preterm infants: a call to standardize echocardiographic screening and follow-up policy

Sanne Arjaans, Elvira A. H. Zwart, Marc Roofthooft, Elisabeth M. W. Kooi, Arend F. Bos, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen and University of GroningenNetherlands European Journal of PediatricsEur J Pediatr 2021; 180: 1855-1865DOI: 10.1007/s00431-021-03931-5 AbstractPulmonary hypertension (PH) is a frequent complication in extremely preterm born infants that seriously affects outcome. We

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