Class 3. Pulmonary Hypertension Associated with Lung Disease

Extremely premature infants born at 23-25 weeks gestation are at substantial risk for pulmonary hypertension

Hannes Sallmon, Martin Koestenberger, Alexander Avian, Friedrich Reiterer, Bernhard Schwaberger, Katharina Meinel, Gerhard Cvirn, Stefan Kurath-Koller, Andreas Gamillscheg, Georg HansmannEuropean Pediatric Pulmonary Vascular Disease Network. Charité-Universitätsmedizin Berlin. Deutsches Herzzentrum Berlin. Medical University Graz. Hannover Medical School. Germany and Austria Journal of PerinatologyJ Perinatol 2022; 42: 781-787DOI: 10.1038/s41372-022-01374-w AbstractObjective: Extremely low gestational age newborns (ELGANs) represent an especially […]

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Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension

Mayank Sharma, Michael A. Bellio, Merline Benny, Shathiyah Kulandavelu, Pingping Chen, Chawisa Janjindamai, Chenxu Han, Liming Chang, Shanique Sterling, Kevin Williams, Andreas Damianos, Sunil Batlahally, Kaitlyn Kelly, Daniela Aguilar-Caballero, Ronald Zambrano, Shaoyi Chen, Jian Huang, Shu Wu, Joshua M. Hare, Augusto Schmidt, Aisha Khan, Karen YoungUniversity of Miami Miller School of Medicine.United States Stem Cells Translational Medicine Stem Cells Transl Med 2022; 11: 828-840DOI: 10.1093/stcltm/szac041 AbstractMesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary

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Factors associated with discontinuation of pulmonary vasodilator therapy in children with bronchopulmonary dysplasia-associated pulmonary hypertension

Catherine M. Avitabile, Xuemei Zhang, Steve B. Ampah, Yan Wang, Devon Ash, Kathleen Nilan, Laura Mercer-Rosa, Julie L. Fierro, David B. Frank, Kathleen A. GibbsUniversity of Pennsylvania and Children’s Hospital of Philadelphia.United States Journal of PerinatologyJ Perinatol 2022; 42: 1246-1254DOI: 10.1038/s41372-022-01421-6 AbstractObjective: To evaluate factors associated with discontinuation of pulmonary vasodilator therapy in bronchopulmonary dysplasia-related pulmonary hypertension

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Late onset of pulmonary hypertension in very low birth weight infants

Joseph Ginski, Dmitry Tumin, Devon Kuehn, Jason Higginson, Scott MacGilvrayEast Carolina UniversityUnited States Journal of Maternal Fetal and Neonatal MedicineJ Matern Fetal Neonatal Med 2022; 35: 3516-3518DOI: 10.1080/14767058.2020.1826924 AbstractIntroduction: Pulmonary hypertension (PH) is a recognized complication of bronchopulmonary dysplasia (BPD). Recent guidelines recommend evaluating all infants with BPD for PH via echocardiogram, but the specific timing of this screening

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The Clinical and Cost Utility of Cardiac Catheterizations in Infants with Bronchopulmonary Dysplasia

Emily L. Yang, Philip T. Levy, Paul J. Critser, Dmitry Dukhovny, Patrick D. EversOregon Health and Sciences University. Harvard Medical School and Boston Children’s Hospital. Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center.United States Journal of PediatricsJ Pediatr 2022; 246: 56-63DOI: 10.1016/j.jpeds.2022.04.009

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Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

Danielle S. Roberts, Laura G. Sherlock, Janelle N. Posey, Jamie L. Archambault, Eva S. Nozik, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus.United States Physiological ReportsPhysiol Rep 2022; 10: DOI: 10.14814/phy2.15482 AbstractSerotonin (5-hydroxytryptamine, 5-HT) is a potent pulmonary vasoconstrictor and contributes to high pulmonary vascular resistance in the developing ovine lung. In experimental pulmonary hypertension (PH), pulmonary expression of tryptophan hydroxylase-1 (TPH1),

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Pulmonary Hypertension in Preterm Infants Treated With Laser vs Anti-Vascular Endothelial Growth Factor Therapy for Retinopathy of Prematurity

Christopher R. Nitkin, Nicholas A. Bamat, Joanne Lagatta, Sara B. DeMauro, Henry C. Lee, Ravi Mangal Patel, Brian King, Jonathan L. Slaughter, J. Peter Campbell, Troy Richardson, Tamorah LewisUniversity of Missouri Kansas City School and Children’s Mercy Hospital. University of Pennsylvania and Children’s Hospital of Philadelphia. Medical College of Wisconsin. Stanford University. Emory University and

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Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study

Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep HarigopalNewcastle University and Royal Victoria Infirmary. United Kingdom Archives of Disease in Childhood. Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2022; 107: 13-19DOI: 10.1136/archdischild-2021-322001 AbstractObjectives: To assess the minimum incidence of life-threatening bronchopulmonary dysplasia (BPD), defined as need for positive pressure respiratory support or pulmonary vasodilators

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Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study

Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel GanzevoortUniversity of Amsterdam and Emma Children’s Hospital. University of Groningen, University Medical Center Groningen and Beatrix Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Leiden University Medical Center. Erasmus University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2022; 181: 1709-1718DOI: 10.1007/s00431-021-04355-x AbstractThe aim was

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Clinical Significance of Early Pulmonary Hypertension in Preterm Infants

Sanne Arjaans, Marian W. F. Fries, Mirthe H. Schoots, Carine F. M. Schilte, Marc T. R. Roofthooft, Elianne J. L. E. Vrijlandt, Arie F. Bos, Elisabeth M. W. Kooi, Rolf M. F. BergerUniversity of Groningen, Beatrix Children’s Hospital and University Medical Center Groningen.Netherlands Journal of PediatricsJ Pediatr 2022; 251: 74-81DOI: 10.1016/j.jpeds.2022.07.039 AbstractObjective: To characterize different phenotypes of

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