Class 3. Pulmonary Hypertension Associated with Lung Disease

Diagnosis and management of pulmonary hypertension in infants with bronchopulmonary dysplasia: a guide for paediatric respiratory specialists

Sarah Chan, Rossa Brugha, Sadia Quyam, Shahin MoledinaGreat Ormond Street Hospital for Children. NHS Foundation Trust. University College London, London. United Kingdom BreatheBreathe 2022; 18: DOI: 10.1183/20734735.0209-2022 AbstractPulmonary hypertension (PH) can develop in babies with bronchopulmonary dysplasia (BPD). PH is common in those with severe BPD and is associated with a high mortality rate. However, in […]

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First Genotype-Phenotype Study in TBX4 Syndrome: Gain-of-Function Mutations Causative for Lung Disease

Matina Prapa, Mauro Lago-Docampo, Emilia M. Swietlik, David Montani, Melanie Eyries, Marc Humbert, Carrie L. Welch, Wendy K. Chung, Rolf M. F. Berger, Harm Jan Bogaard, Olivier Danhaive, Pilar Escribano-Subıas, Henning Gall, Barbara Girerd, Ignacio Hernandez-Gonzalez, Simon Holden, David Hunt, Samara M. A. Jansen, Wilhelmina Kerstjens-Frederikse, David G. Kiely, Pablo Lapunzina, John McDermott, Shahin Moledina,

First Genotype-Phenotype Study in TBX4 Syndrome: Gain-of-Function Mutations Causative for Lung Disease Read More »

Hypoxic preconditioning improves the survival and pro-angiogenic capacity of transplanted human umbilical cord mesenchymal stem cells via HIF-1α signaling in a rat model of bronchopulmonary dysplasia

Chang Hao, Jingyi You, Huijun Qiu, Ou Zhou, Jiang Liu, Wenjing Zou, Ke Yeng, Zhou Fu, Lin ZouChildren’s Hospital of Chongqing Medical University. China Biochemical and Biophysical Research CommunicationsBiochem Biophys Res Commun 2022; 605: 111-118DOI: 10.1016/j.bbrc.2022.03.044 AbstractBronchopulmonary dysplasia (BPD) is a serious chronic respiratory disease that predominates in the neonatal period. Currently, efficacious and effective specific

Hypoxic preconditioning improves the survival and pro-angiogenic capacity of transplanted human umbilical cord mesenchymal stem cells via HIF-1α signaling in a rat model of bronchopulmonary dysplasia Read More »

Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant

Motaharehsadat Heydarian, Prajakta Oak, Xin Zhang, Nona Kamgari, Alida Kindt, Markus Koschlig, Tina Pritzke, Erika Gonzalez- Rodriguez, Kai Förster, Rory E Morty, Friederike Häfner, Christoph Hübener, Andreas W Flemmer, Ali Oender Yildirim, Deepti Sudheendra, Xuefei Tian, Agnese Petrera, Holger Kirsten, Peter Ahnert, Nick Morrell, Tushar J Desai, Jennifer Sucre, Edda Spiekerkoetter, Anne HilgendorffHelmholtz Zentrum München.

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Risk factors that affect the degree of bronchopulmonary dysplasia in very preterm infants: a 5-year retrospective study

Tingting Yang, Qianqian Shen, Siyu Wang, Tianfang Dong, Liang Liang, Fan Xu, Youfang He, Chunlei Li, Fang Luo, Jiahong Liang, Chunhui Tang, Jinghui YangKunming University of Science and Technology. The First People’s Hospital of Yunnan Province. Dali University. The First Hospital of Kunming. Yunnan University of Traditional Chinese Medicine. The Affiliated Hospital of Kunming University

Risk factors that affect the degree of bronchopulmonary dysplasia in very preterm infants: a 5-year retrospective study Read More »

Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants

Jason C. Lao, Christine B. Bui, Merrin A. Pang, Steven X. Cho, Ina Rudloff, Kirstin Elgass, Jan Schroder, Anton Maksimenko, Niamh E. Mangan, Malcolm R. Starkey, Elisabeth M. Skuza, Yu B. Y. Sun, Friederike Beker, Clare L. Collins, Omar F. Kamlin, Kai Konig, Atul Malhotra, Kenneth Tan, Chritiane Theda, Morag J. Young, Catriona A. McLean,

Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants Read More »

Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia

Brittany Ann Ruschkowski, Yousef Esmaeil, Kate Daniel, Chantel Gaudet, Behzad Yeganeh, David Grynspan, Robert P. JankovChildren’s Hospital of Eastern Ontario Research Institute. University of Ottawa.Canada American Journal of Respiratory and Critical Care MedicineAm J Respir Crit Care Med 2022; 205: 685-699DOI: 10.1164/rccm.202104-1021OC AbstractRationale: Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective

Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia Read More »

Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis

Maria Anifanti, Stavros Giannakoulakos, Elpis Hatziagorou, Asterios Kampouras, John Tsanakas, Asterios Deligiannis, Evangelia KouidiAristotle University of Thessaloniki and Hippokration Hospital. Greece SensorsSensors 2022; 22: DOI: 10.3390/s22134884 AbstractSeveral studies have shown that patients with cystic fibrosis (CF), even at a young age, have pulmonary and cardiac abnormalities. The main complications are cardiac right ventricular (RV) systolic and/or

Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis Read More »

Risk Factors of Neonatal Acute Respiratory Distress Syndrome Based on the Montreux Definition in Neonates with Sepsis: A Retrospective Case-Control Study

Ya Hu, Kinhong Chen, Fang Wang, Chun Li, Weighong Yue, Hong WeiChildren’s Hospital of Chongqing Medical University. Ministry of Education Key Laboratory of Child Development and Disorders. National Clinical Research Center for Child Health and Disorders (Chongqing). China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key Laboratory of Pediatrics.China

Risk Factors of Neonatal Acute Respiratory Distress Syndrome Based on the Montreux Definition in Neonates with Sepsis: A Retrospective Case-Control Study Read More »

Clinical characteristics and outcomes in neonates with perinatal acute respiratory distress syndrome in China: A national, multicentre, cross-sectional study

Long Chen, Jie Li, Yuan Shi, Chinese Neonatal ARDS (ChiNARDS) study groupChildren’s Hospital of Chongqing Medical University. The First Affiliated Hospital of Chongqing Medical University.China eClinicalMedicineeClinicalMedicine 2022; 55: DOI: 10.1016/j.eclinm.2022.101739 AbstractBackground: Neonatal acute respiratory distress syndrome (NARDS) was defined in 2017 and the epidemiological data remain unknown. Our objective was to explore aetiological factors, clinical characteristics and

Clinical characteristics and outcomes in neonates with perinatal acute respiratory distress syndrome in China: A national, multicentre, cross-sectional study Read More »

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