Class 3. Pulmonary Hypertension Associated with Lung Disease

The emerging roles of SUMOylation in pulmonary diseases

Xuyang Zheng, Lingqiao Wang, Zhen Zhang, Huifang TangThe Affiliated Hangzhou First People’s Hospital, Zhejiang Respiratory Drugs Research Laboratory and Zhejiang University School of Medicine. China Molecular MedicineMol Med 2023; 29: DOI: 10.1186/s10020-023-00719-1 AbstractSmall ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair,

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Pulmonary vein stenosis: prematurity and associated conditions

David M. Drossner, Dennis W. Kim, Kevin O. Maher, William T. MahleEmory University School of Medicine.United States PediatricsPediatrics 2008; 122: e656-e661DOI: 10.1542/peds.2008-0075 AbstractObjective: Pulmonary vein stenosis is a rare, although often lethal, anomaly. Risk factors for the diagnosis of pulmonary vein stenosis are poorly characterized. In this study we sought to identify factors associated with pulmonary vein

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Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture

Hanadi Almazroue, Yi Lin, Leif D. Nelin, John C. Barba II, Avante D. Milton, Jennifer K. TrittmannAbigail Wexner Research Institute at Nationwide Children’s Hospital. The Ohio State University College of Medicine.United States American Journal of Physiol Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L360-L367DOI: 10.1152/ajplung.00433.2021 AbstractBronchopulmonary dysplasia (BPD) is the

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Risk factors and neonatal outcomes of pulmonary air leak syndrome in extremely preterm infants: A nationwide descriptive cohort study

Seong Hee Oh, Hyun-Seung Jin, Chan-Hoo ParkUniversity of Ulsan College of Medicine and Gangneung Asan Hospital. Gyeongsang National University College of Medicine and Gyeongsang National University Changwon Hospital.Republic of Korea MedicineMedicine 2023; 102DOI: 10.1097/MD.0000000000034759 AbstractMost extremely preterm infants (EPIs), who were born before 28 weeks of gestation, with pulmonary air leak syndrome (ALS) are symptomatic, often

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Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative – Group 3 Pulmonary Hypertension

Lucilla Piccari, Brian Allwood, Katerina Antoniou, Jonathan H. Chung, Paul M. Hassoun, Sylvia M. Nikkho, Rajan Saggar, Oksana A. Shlobin, Patrizio Vitulo, Steven D. Nathan, Stephen John WortHospital del Mar. Stellenbosch University and Tygerberg Hospital. University of Crete School of Medicine. The University of Chicago. Johns Hopkins University. Bayer AG. University of California Los Angeles

Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative – Group 3 Pulmonary Hypertension Read More »

Short-time mortality and severe complications of very premature infants-a multicenter retrospective cohort study from Jiangsu Province during 2019-2021

Ya Pan, Huaiyan Wang, Yan Xu, Xiaohua Zhang, Xiaoqing Chen, Xueting Liu, Songlin Liu, Yan Gao, Weiwei Hou, Zhaojun Pan, Xinping Wu, Mei Xue, Mingfu Wu, Huimin Ju, Weimin Wu, Shuping HanWomen’s Hospital of Nanjing Medical University and Nanjing Maternity and Child Health Care Hospital. Changzhou Maternity and Child Health Care Hospital. Affiliated Hospital of

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Intravenous sildenafil for treatment of early pulmonary hypertension in preterm infants

Lukas Schroeder, Paulina Monno, Brigitte Strizek, Till Dresbach, Andreas Mueller, Florian KipfmuellerUniversity Children’s Hospital Bonn and University Hospital Bonn.Germany Scientific ReportsSci Rep 2023; 13DOI: 10.1038/s41598-023-35387-y AbstractData is lacking on the effect of continuous intravenous sildenafil treatment in preterm infants with early pulmonary hypertension (PH), especially in very low birth weight (VLBW) infants. Preterm infants (< 37

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Evaluation of preterm infants having bronchopulmonary dysplasia with echocardiography and serum biomarkers

O. Pamukcu, N. Narin, S. Sunkak, A. TuncayErciyes University School of Medicıne.Turkey Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123001361 AbstractBackground and objectives: Pulmonary hypertension is frequent in infants with bronchopulmonary dysplasia. Echocardiography is easy to perform, non-invasive, and recommended by guidelines even though solely it is not enough. Catheterisation is gold standard but invasive, expensive, and

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Efficacy of Sildenafil in Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

Kacie Dillon, Vineet Lamba, Ranjit R. Philip, Mark F. Weems, Ajay J. Talati University of Tennessee Health Science Center.United States ChildrenChildren 2023; DOI: 10.3390/children10081397 AbstractBackground: Pulmonary hypertension (PH) is a common comorbidity in infants with bronchopulmonary dysplasia (BPD). Sildenafil is a widely recognized therapy for PH, but its efficacy in infants with BPD is questionable. We propose

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The role of rhIGF-1/BP3 in the prevention of pulmonary hypertension in bronchopulmonary dysplasia and its underlying mechanism

Sehua Qu, Lianqiang Shan, Xin Chen, Zhen Zhang, Yumeng Wu, Yun Chen, Feixiang Zhuo, Yitong Wang, Huaifu DongThe First Affiliated Hospital of Bengbu Medical College. China BioMed Central Pulmonary MedicineBMC Pulm Med 2023; 23: DOI: 10.1186/s12890-023-02498-1 AbstractBackground: This study aimed to determine whether postnatal treatment with recombinant human IGF-1 (rhIGF-1)/binding peptide 3 (BP3) ameliorates lung injury and

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