Class 2. Pulmonary Hypertension Associated with Left Ventricular Systolic or Diastolic Dysfunction

Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report

C. Noah Nilsson, Othman A. Aljohani, Michael A. Smith, Rachelle Durand, Inger Norlyk Sheyanth, Hythem Nawaytou, Elliot Stieglitz, Russel Valle, Sanjeev A. DatarUniversity of California San Francisco. Copenhagen University Hospital. United States and Denmark Clinical Case ReportsClin Case Rep 2026; 14:DOI: 10.1002/ccr3.72831 AbstractThis case describes a female infant with RAF1-related Noonan syndrome who developed severe hypertrophic obstructive

Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report Read More »

Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with

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Atrial fibrillation-induced severe left ventricular dysfunction postmitral valve replacement in an adolescent with rheumatic mitral regurgitation

Raghuraj Chawla, Yash Shrivastava, Anish Gupta, Bhanu DuggalAll India Institute of Medical Science Rishikesh.India British Medical Journal Case ReportsBMJ Case Rep 2026; 19: DOI: 10.1136/bcr-2025-267313 AbstractAn adolescent boy with a history of chronic rheumatic heart disease (RHD) and severe mitral regurgitation presented with progressive exertional dyspnoea and palpitations. Echocardiography revealed preserved left ventricular function preoperatively, and

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Use of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors in Pulmonary Hypertension

Benoit Aguado, Grégoire Ruffenach, Thomas Lacoste-Palasset, Agnes Görlach, Marianne Riou, Mathieu Gourmelon, Fabrice Bauer, Marc Humbert, Valerie Schini-Kerth, Jean-Luc Vachiéry, David Montani, Fabrice AntignyUniversité Paris-Saclay and French National Institute for Health and Medical Research. Hôpital Bicêtre and Hôpital Marie Lannelongue. Technical University Munich and German Centre for Cardiovascular Research. Nouvel Hôpital Civil and University Hospital

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Volume Loading May Compromise Left Ventricular Filling in Patients with a Borderline Hypoplastic Left Ventricle

Machi Yamashita, Hirofumi Saiki, Kanchi Saito, Akira Sato, Seiko Kuwata, Satoshi Nakano, Hideaki Senzaki, Junichi KoizumiIwate Medical University. Nihon Institute of Medical Science.Japan International Heart JournalInt Heart J 2025; 66: 1019-1024DOI: 10.1536/ihj.25-216 AbstractGiven the high prevalence of end-organ damage in the long term after the Fontan procedure, patients presenting with borderline hypoplastic left ventricle (LV) are

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Cause of death in children with heart disease: a cohort study

Neil Derridj, Daphné Madec, Olivier Raisky, Sophie Malekzadeh-Milani, Diala Khraiche, Antoine Legendre, Lucile Houyel, Zahra Belhadjer, Franck Iserin, Mathilde Méot, Marilyne Levy, Bertrand Stos, Daniela Laux, Victor Waldmann, Vanessa Lopez, Ayman Haydar, Segolene Bernheim, Régis Gaudin, Fanny Bajolle, Damien Bonnet, Members of M3C Necker Collaborative GroupHôpital Universitaire Necker-Enfants Malades. Paris Cité University. France Archives of

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Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study

Jian-Jian Yu, Jian-Ge Han, Yi Tan, Jian-Xiang Xu, Amanda LeBlanc, Bradley B. Keller, Jiapeng Huang, Lu CaiUniversity of Louisville School of Medicine. Tianjin University Chest Hospital. Cincinnati Children’s Heart Institute and University of Cincinnati. United States and China World Journal of DiabetesWorld J Diabetes 2025; 13: DOI: 10.4239/wjd.v16.i10.109526 AbstractBackground: Diabetes has become a widespread metabolic disease affecting

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Mitochondrial cardiomyopathies: navigating through different clinical and management pictures between adult and paediatric forms

Rachele Adorisio, Nicoletta Cantarutti, Barbara Siri, Elisa Bellettini, Gessica Ingrasciotta, Erica Mencarelli, Francesca Graziani, Rosa Lillo, Sara Di Marzio, Corrado Di Mambro, Fabrizio Drago, Antonio Amodeo, Diego MartinelliBambino Gesù Children’s Hospital. University of Turin. Fondazione Policlinico Universitario A. Gemelli.Italy Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2025; 12: DOI: 10.3389/fcvm.2025.1621096 AbstractMitochondrial diseases (MD) represent a group of

Mitochondrial cardiomyopathies: navigating through different clinical and management pictures between adult and paediatric forms Read More »

Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up

Asad Nawaz, Zixian Sheng, Muhammad Junaid Akram, Jianjin Li, Lingjuan Liu, Yuxing Yuan, Jie TianNational Clinical Research Center for Child Health and Disorders and Children’s Hospital of Chongqing Medical University.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2025; 15: DOI: 10.3389/fcvm.2025.1541651 AbstractBackground: Pediatric cardiomyopathies are rare but life-threatening conditions with high mortality. Limited data exists on their clinical

Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up Read More »

Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta

Ahmed Younis, Yogesh N. V. Reddy, William R. Miranda, Ahmed T. Abdelhalim, Barry A. Borlaug, Heidi M. Connolly, Alexander C. EgbeMayo Clinic.United States International Journal of Cardiology Heart and VasculatureInt J Cardiol Heart Vasc 2025; 57: DOI: 10.1016/j.ijcha.2025.101626 AbstractBackground: Pulmonary hypertension (PH) affects 20% of adults with coarctation of aorta (COA). What is not known is whether

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