Class 1. Pulmonary Hypertension Associated with Inflammation Archives

Mapping the evolving landscape: a bibliometric analysis of macrophages research in bronchopulmonary dysplasia (1990-2025)-a Web of Science Core Collection-based study

Hanzhou Guan, Huaiqing YinChildren’s Hospital Affiliated to Shanxi Medical University and First Hospital of Shanxi Medical University.China Translational PediatricsTransl Pediatr 2026; DOI: 10.21037/tp-2026-0236 AbstractBackground: Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity, and macrophages are increasingly recognized as important drivers of lung injury and repair. We therefore performed a bibliometric analysis to map research trends, key […]

Mapping the evolving landscape: a bibliometric analysis of macrophages research in bronchopulmonary dysplasia (1990-2025)-a Web of Science Core Collection-based study Read More »

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

Bronchiectasis in Inborn Errors of Immunity: Prevalence, Predictors, and Cardiopulmonary Complications in a Genetically Characterized Cohort

Diana Marangu-Boore, Katherine Myint-Hpu, Esther Kang, Luigi D. Notarangelo, Ottavia M. DelmonteNational Institutes of Health. University of Nairobi. United States and Kenya Journal of Clinical ImmunologyJ Clin Immunol 2026; DOI: 10.1007/s10875-026-02044-8 AbstractPurpose: Bronchiectasis poses a serious but incompletely defined burden in patients with inborn errors of immunity (IEI). We determined its prevalence, independent predictors, and cardiopulmonary complications

Bronchiectasis in Inborn Errors of Immunity: Prevalence, Predictors, and Cardiopulmonary Complications in a Genetically Characterized Cohort Read More »

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng-Jun Hu, Claudia Mickael, Yen-Rei Yu, Rubin M. Tuder, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus.United States Comprehensive PhysiologyCompre Physiol 2026; 16: DOI: 10.1002/cph4.70133 AbstractThere is strong evidence supporting inflammatory and autoimmune processes in the pathogenesis of pulmonary arterial hypertension (PAH), although the initiating

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions Read More »

Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature

Sixie Zheng, Hao Li, Siqi She, Yiting Xue, Debao Li, Jiapei Wang, Jing Wang, Yuqing Hu, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. Affiliated Women and Children’s Hospital of Ningbo University. China Frontiers in ImmunologyFront Immunol 2026; 17: DOI: 10.3389/fimmu.2026.1780303

Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature Read More »

GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation

Ruoxuan Jiang, Liuyi Li, Yuhang Luo, Wen Wang, Xiaoya Zeng, Cheng Qian, Chen Gong, Jianlong ShenSecond Affiliated Hospital of Anhui Medical University. First Affiliated Hospital of Anhui Medical University. China International ImmunopharmacologyInt Immunopharmacol 2026; DOI: 10.1016/j.intimp.2026.116394 AbstractPulmonary arterial hypertension (PAH) is a fatal disease marked by pulmonary vascular remodeling. Although endothelial dysfunction and immune cell infiltration

GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation Read More »

Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease

Kiana L. Chen, Stacey Duemmel, Michael Christof, Gaochan Wang, H. Mark Kenney, Marc Nuzzo, Qingfu Xu, Benjamin Korman, Homaira RahimUniversity of Rochester Medical Center. United States Public Library of Science OnePLOS One 2026; 21: DOI: 10.1371/journal.pone.0340677 AbstractComplement’s role in the pathology of rheumatoid arthritis and pulmonary hypertension (PH) is not fully understood. We aimed to determine

Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease Read More »

A Novel Rat Model for Group 2 Pulmonary Hypertension by Total Pulmonary Vein Banding: Multi-Omics Insights into Pathophysiological Mechanisms

Jin Shentu, Wenxuan Dai, Chang Chen, Jiawei Huang, Lijun Chen, Yi Yan, Han Zhang, Zhongqun Zhu, Guocheng Shi, Huiwen ChenShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. China Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2026; DOI: 10.1016/j.jtcvs.2026.01.017 AbstractObjectives: Group 2 pulmonary hypertension (PH) remains a highly morbid disease, yet no

A Novel Rat Model for Group 2 Pulmonary Hypertension by Total Pulmonary Vein Banding: Multi-Omics Insights into Pathophysiological Mechanisms Read More »

Gut Microbiota in Pulmonary Arterial Hypertension: Murine Models and Human Microbial Signatures, Pathogenic Mechanisms, and Emerging Therapeutic Avenues

Yudan Qiu, Xiaojiang Lyu, Dashuang Zhang, Hong Xu, Xu He, Jiao Chen, Hanmin Liu, Yang Liu, Liang XieWest China Second University Hospital and Sichuan University. School of Life Sciences of Fudan University and West China Institute of Women and Children’s Health. Affiliated Hospital of North Sichuan Medical College. Affiliated Hospital of Southwest Medical University. Xizang

Gut Microbiota in Pulmonary Arterial Hypertension: Murine Models and Human Microbial Signatures, Pathogenic Mechanisms, and Emerging Therapeutic Avenues Read More »

Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study

Hamdy El-Sayed, Hala Elmarsafawy, Basma Shouman, Mostafa Mansour, Amal OsmanMansoura University.Egypt Archive de PédiatrieArch Pediatr 2025; DOI: 10.1016/j.arcped.2025.08.004 AbstractBackground: Pediatric pulmonary arterial hypertension (PAH) is a potentially fatal disease. New targeted therapies based on the underlying pathogenesis are still needed.Objective: This study aims to evaluate the role of leukotriene E4, an inflammatory mediator, in developing pediatric pulmonary arterial

Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study Read More »