Class 1. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease

Left Innominate Artery With Anomalous Origin From the Pulmonary Trunk: A Case Report of an Unnoticed Malformation

Juan D. Ayala Torres, Marcia Mejía Velasquez, Mónica Royero-AriasUniversidad de Antioquia. Clínica las Américas. Servicios de Salud San Vicente Fundación.Columbia CureusCureus 2025; 17: DOI: 10.7759/cureus.79661 AbstractThoracic vascular congenital anomalies are malformations with significant clinical implications. One of the rarest anomalies is the anomalous origin of the brachiocephalic trunk from the pulmonary trunk, often associated with serious […]

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High Altitude May Protect Against the Early Development of Irreversible Pulmonary Hypertension in Patients With Congenital Heart Disease

Inge von Alvensleben, Brian B. Graham, Gustavo A. Balanza, Carlos Brockmann, Ericka C. Pérez, Ximena Y. Vicente, Carla Arteaga, Claudia Scherer, Franz P. Freudenthal, Rubin M. Tuder, Alexandra HeathKardiozentrum. University of Colorado. University of California San Francisco. Massachusetts General Hospital and Harvard Medical School. Hospital Belga.Bolivia and United States Pulmonary CirculationPulm Circ 2025; 15:  DOI: 10.1002/pul2.70049

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Pathogenic SMAD6 variants in patients with idiopathic and complex congenital heart disease associated pulmonary arterial hypertension

Sofia Karl, Ekkehard Grünig, Memoona Shaukat, Matthias Held, Christian Apitz, Fabian von Scheidt, Ralf Geiger, Michael Halank, Karen M. Olsson, Marius M. Hoeper, Jan C. Kamp, Gabor Kovacs, Horst Olschewski, Hans-Jürgen Seyfarth, Katrin Milger, Ralf Ewert, Hans Klose, Benjamin Egenlauf, Panagiota Xanthouli, Katrin Hinderhofer, Christina A. EichstaedtHeidelberg University Hospital and Heidelberg University. KWM Missio Clinic.

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Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children

Yanyun Huang, Yuting Chen, Danyan Su, Suyuan Qin, Cheng Chen, Dongli Liu, Bingbing Ye, Yuqin Huang, Piaoliu Yuan, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University. China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1562782 AbstractBackground: Transcatheter closure is now the preferred treatment for congenital heart disease complicated with pulmonary arterial hypertension (CHD-PAH), but its long-term effects

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Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation

Benjamin S. Frank, Sierra Niemiec, Ludmila Khailova, Christopher A. Mancuso, Max B. Mitchell, Gareth J. Morgan, Mark Twite, Michael V. DiMaria, Carmen C. Sucharov, Jesse A. DavidsonUniversity of Colorado. University of Michigan.United States Journal of the American College of Cardiology AdvancesJACC Adv 2025; 4: DOI: 10.1016/j.jacadv.2025.101672 AbstractBackground: Endothelin-1 (ET1) is a potent vasoconstrictor and stimulator of pulmonary

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Airway Anomalies Predict Risk of Pediatric Pulmonary Hypertension

Elana R. Kriegel, Aditya Srinivasen, Luke Mammen, Harini Venkataganesh, Jess T. Randall, Lara ReichertAlbany Medical College and Albany Medical Center.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71028 AbstractIntroduction: Pediatric pulmonary hypertension (PH) significantly contributes to morbidity and mortality due to the progressive nature of the disease in some subtypes, which leads to severe right heart failure,

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Long-term survival of shunt closure in atrial septal defects with pulmonary arterial hypertension

Wenjie Chen, Jingyuan Chen, Min Peng, Jun Luo, Haihua Qiu, Yusi Chen, Jiang LiSecond Xiangya Hospital of Central South University. China International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.133094 AbstractObjective: This study aims to refine closure indications and assess long-term outcomes in pulmonary arterial hypertension associated with atrial septal defect (PAH-ASD).Methods: We enrolled 197 PAH-ASD patients classified

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Pulmonary artery systolic pressure associated with inflammatory factors among pediatric congenital heart disease with pulmonary arterial hypertension after cardiopulmonary bypass

WenJuan Li, Wenyuan Shang, Jihong HuangXinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine.China Jornal de PediatriaJ Pediatr 2025; DOI: 10.1016/j.jped.2025.01.006 AbstractObjective: This study aimed to evaluate the perioperative inflammatory cytokines in pediatric patients with pulmonary arterial hypertension secondary to congenital heart disease and also sought to investigate the correlation between preoperative echocardiographic pulmonary artery

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Ultrasonographic diagnosis and follow-up of a special type of giant fetal hepatic hemangioma

Xiaoyan Weng, Juan Jiang, Gang WenWomen and Children’s Hospital Affiliated to Ningbo University. China Pediatric RadiologyPediatr Radiol 2025; DOI: 10.1007/s00247-025-06196-4 AbstractWe present a case of giant fetal hepatic hemangioma to illustrate the impact of ultrasound monitoring on treatment outcomes. Prenatal ultrasound revealed cardiac enlargement, leading to a cesarean section. The neonate had multiple vascular anomalies, including

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Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta

Ahmed Younis, Yogesh N. V. Reddy, William R. Miranda, Ahmed T. Abdelhalim, Barry A. Borlaug, Heidi M. Connolly, Alexander C. EgbeMayo Clinic.United States International Journal of Cardiology Heart and VasculatureInt J Cardiol Heart Vasc 2025; 57: DOI: 10.1016/j.ijcha.2025.101626 AbstractBackground: Pulmonary hypertension (PH) affects 20% of adults with coarctation of aorta (COA). What is not known is whether

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