Class 1. Idiopathic Pulmonary Hypertension

Reduced pulmonary arterial compliance predicts poor short-term outcome in children with pulmonary arterial hypertension independent of pulmonary vascular resistance

Eva Gouwy, Mark-Jan Ploegstra, Meindina G. Haarman, Marcus T. R. Roofthooft, Rolf M. F. Berger, Johannes M. DouwesBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen.Netherlands Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2025; 12: DOI: 10.3389/fcvm.2025.1526435 AbstractBackground and study aim: Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease with pulmonary vascular remodelling leading […]

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Pediatric lung transplantation in China, 2019-2023

Xiao‑Shan Li, Zi‑Tao Wang, Bo Wu, Shu‑Gao Ye, Feng Liu, Chun‑Xiao Hu, Yi Lu, Wen‑Jie Hua, Wei‑Wei Xu, Man Huang, Jing‑Yu ChenAffiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center and Nanjing Medical University. Chinese Lung Transplantation Quality Management and Control Center. Wuxi School of Medicine and Jiangnan University. Second

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Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

Bin Liu, Dan Yi, Shuai Li, Karina Ramirez, Xiaomei Xia, Yanhong Cao, Hanqiu Zhao, Ankit Tripathi, Shenfeng Qiu, Mrinalini Kala, Ruslan Rafikov, Haiwei Gu, Vinicio de jesus Perez, Sarah-Eve Lemay, Christopher C. Glembotski, Kenneth S. Knox, Sebastien Bonnet, Vladimir V. Kalinichenko, You-Yang Zhao, Michael B. Fallon, Olivier Boucherat, Zhiyu DaiCollege of Medicine-Phoenix and University of Arizona. Washington University School of Medicine in St. Louis. Guangzhou Medical University. Indiana University College of Medicine. Arizona State University. Stanford University. Laval University. Phoenix Children’s Hospital. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United

Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension Read More »

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3

Bum-Yong Kang, Jiwoong Choi, Victor Tseng, Yutong Zhao, Jing Zhao, Robert S. Stearman, Wilbur A. Lam, Viranuj Sueblinvong, Benjamin T. Kopp, Michael J. Passineau, Changwon Park, John Lister, Raymond J. Benza, Andrew J. JangEmory University School of Medicine. Atlanta Veterans Healthcare System. University of Kansas School of Medicine and University of Kansas. Ansible Health. Ohio

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3 Read More »

MHCIIhiLYVE1loCCR2hi Interstitial Macrophages Promote Medial Fibrosis in Pulmonary Arterioles and Contribute to Pulmonary Hypertension

Fan Qiu, Hao-Ran Miao, Hong-Liang Hui, Lin-Jie Qiu, Yi Chen, Min Luo, Jian-Chao Zhang, Yan-Gui Lin, Dan Li, Sang-Bing Ong, Xue-Fei Hu, Bo Jiang, Yi-Qian ZhangEighth Affiliated Hospital of Sun Yat-sen University. Chinese University of Hong Kong. Hong Kong Children’s Hospital. China and Hong Kong Circulation ResearchCirc Res 2025; DOI: 10.1161/CIRCRESAHA.125.326173 AbstractBackground: Pulmonary hypertension (PH) is a

MHCIIhiLYVE1loCCR2hi Interstitial Macrophages Promote Medial Fibrosis in Pulmonary Arterioles and Contribute to Pulmonary Hypertension Read More »

ThoroughFare atrial pressure controller device to create a controlled interatrial right-to-left shunt in advanced pulmonary arterial hypertension – A pilot study

Bojja Venkata Satya Roopesh, Girija Haritha, S. V. Kishore, Muthukumaran Chinnasamy Sivaprakasam, Shreesha Maiya, Saileela Rajan, Pramod Sagar, Kothandam SivakumarMadras Medical Mission. Apollo Children’s Hospital. Narayana Health. MIOT HospitalIndia Annals of Pediatric CardiologyAnn Pediatr Cardiol 2024; 17: 408-414DOI: 10.4103/apc.apc_209_24 AbstractBackground: Atrial flow regulators are used in patients with pulmonary arterial hypertension (PAH) who present with syncope or

ThoroughFare atrial pressure controller device to create a controlled interatrial right-to-left shunt in advanced pulmonary arterial hypertension – A pilot study Read More »

Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models

Mikala C. Mueller, Rachel Blomberg, Alicia E. Tanneberger, Duncan Davis-Hall, Keith B. Neeves, Chelsea M. MaginUniversity of Colorado. United States American Chemical Society Biomaterials Science and EngineeringACS Biomater Sci Eng 2025; DOI: 10.1021/acsbiomaterials.5c00123 AbstractPulmonary arterial hypertension (PAH) is a form of pulmonary vascular disease characterized by scarring of the small blood vessels that results in reduced

Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models Read More »

Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension

Rebecca L. Harper, Xin Zhou, David P. Marciano, Aiqin Cao, Lingli Wang, Guibin Chen, Mir S. Adil, Wenyu Zhou, Peter Maguire, Shanthi Deivanayagam, Quan Yu, Vignesh Viswanathan, Dan Yang, Marcy Martin, Sarasa Isobe, Shoichiro Otsuki, Jordan Burgess, Audrey Inglis, Devon Kelley, Patricia A. del Rosario, Andrew Hsi, Francois Haddad, Roham T. Zamanian, Manfred Boehm, Michael

Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension Read More »

Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients

Gabriel F. Diaz, Carlos E. Diaz‐Castrillon, Alicia Marquez Garcia, Rachel K. Hopper, Vinicio de J. PerezUniversidad Nacional De Colombia. University of Pittsburgh. Centro Policlínico Del Olaya and Clínica De La Mujer. Stanford University School of Medicine. Columbia and United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70017 AbstractPulmonary hypertension (PH) at high altitudes presents unique characteristics

Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients Read More »

Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension

Christian Westöö, Ayse Ceren Mutgan, Oscar van der Have, Timothy J. Mead, Salaheldin Ahmed, Elna Lampei, Christopher D. Koch, Christian Norvik, Anders Aspberg, Martin Bech, Niccolò Peruzzi, Hans Brunnström, Grazyna Kwapiszewska, Göran Rådegran, Suneel S. Apte, Karin Tran-LundmarkLund University. Medical University of Graz. Skåne University Hospital. Cleveland Clinic Lerner Research Institute. Case Western Reserve University. University Hospitals Rainbow Babies & Children’s Hospital. Helsingborg Hospital. Sanford School of Medicine and University of South Dakota. German Center for Lung Research Sweden, Austria, United States

Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension Read More »

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