Class 1. Idiopathic Pulmonary Hypertension Archives

Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients – An Open-Label Phase 2 Study

Toru Iwasa, Ryo Inuzuka, Hiroshi Ono, Yuichiro Sugitani, Hirokuni Yamazawa, Chihiro Hiraishi, Naoki Shiota, Shinichi Tanaka, Chieko Yamamoto, Ken-ichi Kurosaki, Masaru Miura, Satoshi YasukochiNational Cerebral and Cardiovascular Center. University of Tokyo. National Center for Child Health and Development. Japan Community Health Care Organization Kyushu Hospital. Hokkaido University. Nippon Shinyaku Company. Tokyo Metropolitan Children’s Medical Center. […]

Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients – An Open-Label Phase 2 Study Read More »

Pediatric Pulmonary Arterial Hypertension; is it Possible to Predict its Outcome?

Hala M. Aghaa, Ranya Hegazy, Ahmed Gamal, Ranya Essam, Antoine A. Elmessih, Ahmed Behairy,Nagib Dahdah, Ahmed Abdelwahed, Nesrine Sobhy, Noha AliSpecialized Pediatric Hospital and Cairo University. CHU Sainte Justine and University of Montreal.Egypt and Canada Journal of the Saudi Heart AssociationJ Saudi Heart Assoc 2024; 36: 408-419DOI: 10.37616/2212-5043.1398 AbstractObjectives: To assess the outcome of pediatric pulmonary arterial

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Safety, tolerability, and efficacy of an in-class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension

Cara Morgan, Nikmah Idris, Kathy Elterefi, Luca Di Ienno, Andrew Constantine, Sadia Quyam Roberta Bini, Shahin MoledinaGreat Ormond Street Hospital for Children. Queen Elizabeth Hospital. Institute of Cardiovascular Sciences University College London. United Kingdom Pulmonary CirculationPulm Circ 2024;DOI: 10.1002/pul2.70011 AbstractThe aim of this single-centre retrospective observational study was to evaluate the safety, tolerability, and efficacy of

Safety, tolerability, and efficacy of an in-class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension Read More »

Genetic burden in neonatal and pediatric-onset pulmonary hypertension: A single-center retrospective study using exome sequencing in a Chinese population

Chen Chen Fucheng Li, Hang Zhou, Dan Wang, Fang Fu, Qiuxia Yu, Ruibin Huang, Yan Lu, You Wang, Guilan Chen, Fei Guo, Tingying Lei, Chunlin Ma, Ru LiGuangzhou Women and Children’s Medical Center. Guangzhou Medical University. China Pediatrics and NeonatologyPediatr Neonatol 2024; DOI: 10.1016/j.pedneo.2024.06.010 AbstractObjective: This single-center retrospective study aimed to investigate the genetic factors contributing to

Genetic burden in neonatal and pediatric-onset pulmonary hypertension: A single-center retrospective study using exome sequencing in a Chinese population Read More »

Collapse of an early adolescent girl. Syncope? Simple or sinister?

Graham Martin, Chiara Cavaliere, Nikila Pandya, Krishnan BalasubramanianMaidstone and Tunbridge Wells NHS Trust.United Kingdom British Medical Journals Case ReportsBMJ Case Rep 2024; 17: DOI: 10.1136/bcr-2023-259246 AbstractAn early adolescent girl presented to the emergency department (ED) of her local hospital following a syncopal episode after a warm bath on a background of increasing breathlessness for 1-year duration. On examination, she

Collapse of an early adolescent girl. Syncope? Simple or sinister? Read More »

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension

Dong Hun Lee, Andrew J. Jang, Minseong Kim, Sarah S. Chang, Raham Lee, Juyoung Kim, Jing Ma, Michael J. Passineau, Raymond L. Benza, Harry Karmouty‐Quintana, Benjamin T. Kopp Roy L. Sutliff, Wilbur A. Lam, C. Michael Hart, Changwon Park, Bum‐Yong KangEmory University School of Medicine. Chonnam National University. Louisiana State University Health Science Center. Atlanta

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension Read More »

A Single Center Experience of Pulmonary Arterial Hypertension Management in Korea: A 25-Year Comparative Analysis Following the Introduction of Targeted Therapy

Ji Hyun Cha I-Seok Kang, Shin Yi Jang, June Huh Jeong Hoon Yang, Jinyoung Song, Taek Kyu Park, Seung Woo Park, Hojoong Kim, Duk-Kyung Kim Sung-A ChangSamsung Medical Center, Samsung Changwon Hospital and Sungkyunkwan University School of Medicine. Republic of Korea Korean Circulation JournalKorean Circ J 2024; DOI: 10.4070/kcj.2023.0316 AbstractBackground and objectives: The transformation of pulmonary arterial

A Single Center Experience of Pulmonary Arterial Hypertension Management in Korea: A 25-Year Comparative Analysis Following the Introduction of Targeted Therapy Read More »

Safety and Effectiveness of Selexipag in Pediatric Pulmonary Hypertension: A Retrospective Multi-Center Cohort Study

Benjamin S. Frank, Eliza R. Gentzler, Catherine M. Avitabile, Kathleen Miller-Reed, Zhaoxing Pan, Erika B. Rosenzweig, D. Dunbar Ivy, Usha S. KrishnanUniversity of Colorado School of Medicine and Children’s Hospital Colorado. Columbia University Irving Medical Center and Morgan Stanley Childrens Hospital of New York Presbyterian Hospital. University of Pennsylvania School of Medicine and Children’s Hospital

Safety and Effectiveness of Selexipag in Pediatric Pulmonary Hypertension: A Retrospective Multi-Center Cohort Study Read More »

Pediatric Lung Transplantation for Pulmonary Vascular Diseases: Recent Advances and Challenges

Levent Midyat, Eleanor D. Muise, Gary A. VisnerUniversity of Pittsburgh School of Medicine and Children’s Hospital of Pittsburgh. NYU Grossman School of Medicine and Hassenfeld Children’s Hospital. Harvard Medical School and Boston Children’s Hospital.United states Clinics in Chest MedicineClin Chest Med 2024; 45: 761-769DOI: 10.1016/j.ccm.2024.02.023 AbstractPediatric lung transplantation for pulmonary vascular diseases has seen notable advancements

Pediatric Lung Transplantation for Pulmonary Vascular Diseases: Recent Advances and Challenges Read More »

Biventricular responses to exercise and their relation to cardiorespiratory fitness in pediatric pulmonary hypertension

Guido E. Pieles, Dan-Mihai Dorobantu, Jessica E. Caterini, Barbara Cifra, Janette Reyes, Sara Roldan Ramos, Eilis Hannon, Craig A. Williams, Tilman Humpl, Luc Mertens, Greg D. Wells, Mark K. FriedbergHospital for Sick Children. University of Exeter.Canada and United Kingdom American Joural of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2024; DOI: 10.1152/ajpheart.00096.2024 AbstractDespite

Biventricular responses to exercise and their relation to cardiorespiratory fitness in pediatric pulmonary hypertension Read More »