Medical Therapy. Efficacy or Lack of Efficacy

Novel Therapies for Right Ventricular Failure

Bibhuti B. DasUniversity of Mississippi Medical Center.United States Current Cardiology ReportsCurr Cardiol Rep 2025; 27:DOI: 10.1007/s11886-024-02157-9 AbstractPurpose of review: Traditionally viewed as a passive player in circulation, the right ventricle (RV) has become a pivotal force in hemodynamics. RV failure (RVF) is a recognized complication of primary cardiac and pulmonary vascular disorders and is associated with a […]

Novel Therapies for Right Ventricular Failure Read More »

Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential

Fabian Doktor, Lina Antounians, Rebeca Lopes Figueira, Kasra Khalaj, Miriam Duci, Augusto ZaniHospital for Sick Children and University of Toronto. Leipzig University.Canada and Germany Stem Cells Translational MedicineStem Cells Transl Med 2025; 14: DOI: 10.1093/stcltm/szae095 AbstractDisruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic

Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential Read More »

Systemic Sirolimus Therapy Is Associated With Reduced Intervention Frequency in Pulmonary Vein Stenosis

Alyssa B. Kalustian, Joseph L. Hagan, Paige E. Brlecic, Ionela Iacobas, Rachel D. Vanderlaan, Joseph Burns, Thao T. Wu, Ravi Birla, Sharada Gowda, Manish Bansal, Srinath T. Gowda, Lindsay F. Eilers, Asra Khan, Juan Pablo Sandoval-Jones, Michiaki Imamura, Yishay Orr, Christopher A. Caldarone, Athar M. QureshiTexas Children’s Hospital and Baylor College of Medicine. Hospital for

Systemic Sirolimus Therapy Is Associated With Reduced Intervention Frequency in Pulmonary Vein Stenosis Read More »

Pulmonary Arterial Hypertension Incidence in Scleroderma Patients Treated with Bosentan for Digital Ulcers: Evidence from the Italian SPRING Registry

Fabio Cacciapaglia, Rossella De Angelis, Clodoveo Ferri, Gianluigi Bajocchi, Silvia Bellando-Randone, Cosimo Bruni, Martina Orlandi, Marco Fornaro, Edoardo Cipolletta, Giovanni Zanframundo, Roberta Foti, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Pettiti Giorgio, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Alessandro Giollo, Marta Saracco, Cecilia Agnes, Corrado Campochiaro, Federica Lumetti, Amelia Spinella, Luca Magnani, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Carlo Iandoli, Antonietta Gigante, Greta Pellegrino, Franco Cozzi, Maria Grazia Lazzaroni, Elena

Pulmonary Arterial Hypertension Incidence in Scleroderma Patients Treated with Bosentan for Digital Ulcers: Evidence from the Italian SPRING Registry Read More »

Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients – An Open-Label Phase 2 Study

Toru Iwasa, Ryo Inuzuka, Hiroshi Ono, Yuichiro Sugitani, Hirokuni Yamazawa, Chihiro Hiraishi, Naoki Shiota, Shinichi Tanaka, Chieko Yamamoto, Ken-ichi Kurosaki, Masaru Miura, Satoshi YasukochiNational Cerebral and Cardiovascular Center. University of Tokyo. National Center for Child Health and Development. Japan Community Health Care Organization Kyushu Hospital. Hokkaido University. Nippon Shinyaku Company. Tokyo Metropolitan Children’s Medical Center.

Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients – An Open-Label Phase 2 Study Read More »

Scoping review of initiation criteria for inhaled nitric oxide in preterm infants (born <34 weeks) after 7 days of age

Shin Kato, Yohei Minamitani, Miku Hosokawa, Toshinori Nakashima, Sota Iwatani, Katsuya Hirata, Arata Oda, Takushi Hanita, Masafumi Miyata, Fumihiko Namba, Masayuki Ochiai, Atsushi Nakao, Seiji Yoshimoto, Daichi Suzuki, Erika Ota, Hidehiko Nakanishi, on behalf of the Japan Society for Neonatal Health and DevelopmentJapanese Red Cross Aichi Medical Center Nagoya Daini Hospital. Saitama Medical Center and

Scoping review of initiation criteria for inhaled nitric oxide in preterm infants (born <34 weeks) after 7 days of age Read More »

Sotatercept: A New Era in Pulmonary Arterial Hypertension

Suneesh C. Anand, Muhammad Furqan, Adriano R. Tonelli, Daniela Brady, Avi Levine, Erika B. Rosenzweig, William H. Frishman, Wilbert S. Aronow, Gregg M. LanierHillcrest Hospital and Cleveland Clinic. New York Medical College, Maria Fareri Children’s Hospital of Westchester and  Westchester Medical Center.United States Cardiology in ReviewCardiol Rev 2025; DOI: 10.1097/CRD.0000000000000837 AbstractPulmonary arterial hypertension (PAH) is a

Sotatercept: A New Era in Pulmonary Arterial Hypertension Read More »

Safety, tolerability, and efficacy of an in-class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension

Cara Morgan, Nikmah Idris, Kathy Elterefi, Luca Di Ienno, Andrew Constantine, Sadia Quyam Roberta Bini, Shahin MoledinaGreat Ormond Street Hospital for Children. Queen Elizabeth Hospital. Institute of Cardiovascular Sciences University College London. United Kingdom Pulmonary CirculationPulm Circ 2024;DOI: 10.1002/pul2.70011 AbstractThe aim of this single-centre retrospective observational study was to evaluate the safety, tolerability, and efficacy of

Safety, tolerability, and efficacy of an in-class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension Read More »

The Role of Nitric oxide in the sweep gas for patients receiving Extracorporeal Membrane Oxygenation or Cardiopulmonary Bypass

Roberto Chiletti, Sophie H. Fincher, Stephen B. Horton, Giles J. Peek, Paul Checchia, Warwick ButtRoyal Children’s Hospital and University of Melbourne. University of Florida. Texas Children’s Hospital and the Baylor College of Medicine. Australia and United States Canadian Journal of CardiologyCan J Cardiol 2024; DOI: 10.1016/j.cjca.2024.12.027 AbstractNitric oxide (NO) was proclaimed the 1992 “molecule of the

The Role of Nitric oxide in the sweep gas for patients receiving Extracorporeal Membrane Oxygenation or Cardiopulmonary Bypass Read More »

Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study

Xue-rong Huang, Lian Wang, Guo-bao Liang, Sheng-qian Huang, Bao-ying Feng, Lu Zhu, Xu-fang Fan, Mu-lin Yao, Jing Zhang, Meng-jiao Wang, Zhi Zheng, Yao Zhu, Wen-li Duan, Zhan-kui Li, Jian Mao, Li Ma, Fa-lin Xu, Fan Wu, Qiu-fen Wei, Ling Liu, Xin-zhu LinWomen and Children’s Hospital of Xiamen University School of Medicine. Xiamen Key Laboratory of

Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study Read More »

Scroll to Top