Adult Pulmonary Vascular Disease

Metabolomics of Right Ventricular Function in Pulmonary Hypertension

Jonathan Chacon-Barahona, Samuel J Chung, Jonah D Garry, Robert Frantz, Franz Rischard, Paul M Hassoun, Stephen C Mathai, Catherine E Simpson, Gerald Beck, Nicholas S Hill, Jane A Leopold, Aaron B Waxman, Erika B Rosenzweig, Barry A Borlaug, Monica Mukherjee, Rebecca Vanderpool, Miriam Jacob, Reena Mehra, Margaret M Park, J Emanuel Finet, Samar Farha, Gabriele Grunig, Deborah Kwon, Suzy Comhair, Serpil Erzurum, John Barnard, Bo Hu, Christine L Jellis, Alexandra Christin Racanelli, Jan Krumsiek, Evan L Brittain, Anna Hemnes, Evelyn Horn; PVDOMICS Study GroupWeill Cornell Medical College. Albert […]

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Transcatheter closure of anomalous systemic arterial supply to the left lung from the left subclavian artery: Diagnostic and procedural challenges

Anil Kumar Singhi, Manojit Lodha, Santunu De, Arpita Choraria, Sandip Sardar, Ejaz Ahmed Bari, Debadri ChakrabartiManipal Hospital EM Bypass. Vivekananda Institute of Medical Sciences. India Journal of Cardiology CasesJ Cardiol Cases 2025 Aug 5; 32: 207-210DOI: 10.1016/j.jccase.2025.07.007 AbstractA 26-year-old woman with chronic effort intolerance and a continuous murmur underwent evaluation for suspected congenital heart disease. While

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Protocol for an open-label, randomised, controlled trial to evaluate the efficacy and safety of sotatercept add-on therapy compared with pulmonary vasodilator-based standard of care for pulmonary vasodilator-resistant pulmonary arterial hypertension associated with unrepaired congenital shunts (atrial septal defect, ventricular septal defect or patent ductus arteriosus), including Eisenmenger syndrome: the SuMILE trial

Keimei Yoshida, Kazuya Hosokawa, Takahiro Hiraide, Satoshi Akagi, Kentaro Ejiri, Yu Taniguchi, Shiro Adachi, Takumi Inami, Naohiko Nakanishi, Masaharu Kataoka, Taijyu Satoh, Shunsuke Tatebe, Toshiro Shinke, Hideshi Tomita, Yusuke Akazawa, Takashi Higaki, Koshiro Tagawa, Ayako Ishikita, Soshun Asakawa, Kohtaro AbeKyushu University and Kyushu University Hospital. Keio University School of Medicine. Okayama University. Kobe University Hospital.

Protocol for an open-label, randomised, controlled trial to evaluate the efficacy and safety of sotatercept add-on therapy compared with pulmonary vasodilator-based standard of care for pulmonary vasodilator-resistant pulmonary arterial hypertension associated with unrepaired congenital shunts (atrial septal defect, ventricular septal defect or patent ductus arteriosus), including Eisenmenger syndrome: the SuMILE trial Read More »

Sotatercept in Patients With Eisenmenger Syndrome

Oktay Tutarel, Oliver Miera, Felix BergerDeutsches Herzzentrum der Charité, Freie Universität Berlin and Humboldt-Universität zu Berlin.Germany Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70283 AbstractEisenmenger syndrome represents a complex and severe form of pulmonary arterial hypertension (PAH) associated with congenital heart disease. Sotatercept, a first-in-class activin-signaling inhibitor, offers a novel therapeutic approach in the treatment of PAH,

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Effects of altitude and exercise on pulmonary capillary integrity: evidence for subclinical high-altitude pulmonary edema

Marlowe W. Eldridge, Ruedi K. Braun, Ken Y. Yoneda, William F. WalbyUniversity of Wisconsin.United States Journal of Applied PhysiologyJ Appl Physiol 2006; 100: 972-980 DOI: 10.1152/japplphysiol.01048.2005 AbstractStrenuous exercise may be a significant contributing factor for development of high-altitude pulmonary edema, particularly at low or moderate altitudes. Thus we investigated the effects of heavy cycle ergometer exercise (90%

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Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study

Kevin R. Barker, Andrea L. Conroy, Michael Hawkes, Holly Murphy, Prativa Pandey, Kevin C. KainUniversity of Toronto and University Health Network-Toronto General Hospital. University of Alberta. CIWEC Hospital and Travel Medicine Center. Canada and Nepal Journal of Travel MedicineJ Travel Med 2016; 23: DOI: 10.1093/jtm/taw005 AbstractBackground: The mechanisms underlying acute mountain sickness (AMS) and high-altitude pulmonary edema

Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study Read More »

Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

Claudia Mickael, Jane C. Kabwe, Dara Fonseca Balladares, Annika S. Bai, Kevin Nolan, Michael H. Lee, Rahul Kumar, Joan F. Hilton, Joseph Phiri, Taonga Musonda, Katie Tuscan, Linda Sanders, Kurt R. Stenmark, Paul W. Buehler, Edford Sinkala, David C. Irwin, Sula Mazimba, Brian B. GrahamUniversity of Colorado Anschutz Medical Campus. National Heart Hospital Lusaka and

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Reversible pulmonary hypertension in a patient diagnosed with scurvy

Gregory Berra, Léon Genecand, Anais Juillet, Jean-François Deux, Paco Prada, Hajo Müller, Marco Roffi, Maurice BeghettiGeneva University Hospitals. Switzerland British Medical Journal Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2025-266143 AbstractThis case report describes a woman in her late 50s with reversible pulmonary hypertension (PH) due to scurvy, a rare vitamin C (ascorbic acid) deficiency in

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Secondary pulmonary hypertension in an adult patient with Ebstein anomaly post-atrial septal defect closure; can it be reversible? A case report

Ahmed Kheiwa, Vandad Saadat, Joseph Chung, Stephen Nageotte, Anees RazzoukLoma Linda University Medical Center. European Heart Journal Case ReportsEur Heart J Case Rep 2025; 9: DOI: 10.1093/ehjcr/ytaf527 AbstractBackground: Pulmonary hypertension is often a difficult to diagnose condition, in particular in younger population of patients. Early diagnosis and treatment of this condition is crucial to prevent further morbidity

Secondary pulmonary hypertension in an adult patient with Ebstein anomaly post-atrial septal defect closure; can it be reversible? A case report Read More »

American Lung Association Pulmonary Hypertension Roundtable: Executive Summary

Nicholas Andreas Kolaitis, Sandeep Sahay, Erika Berman Rosenzweig, Deborah Brown, Anna Hemnes, Elizabeth Joseloff, Joy Meyer, Karen A. Pescatore, Albert Rizzo, Namita Sood, Bev Stewart, Vallerie McLaughlin, Tim Williamson, James R. KlingerUniversity of Californian San Francisco School of Medicine. Houston Methodist Hospital. Westchester Medical Center, New York Medical College. American Lung Association. Vanderbilt University. Pulmonary

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