Acquired Patient Factors Associated with Pulmonary Vascular Disease

Identification of potential serum biomarkers for congenital heart disease children with pulmonary arterial hypertension by metabonomics

Nan Jin, Mengjie Yu, Xiaoyue Du2, Zhiguo Wu, Changlin Zhai, Haihua Pan, Jinping Gu, Baogang XieZhejiang University of Technology. Medical College of Jiaxing University. The Second Affiliated Hospital of Nanchang University. China BioMed Central Cardiovascular DisordersBMC Cardiovasc Dis 2023; 23: DOI: 10.1186/s12872-023-03171-5 AbstractBackground: Pulmonary arterial hypertension is a common complication in patients with congenital heart disease. In […]

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Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity

Mona Alotaibi, Junzhe Shao, Michael W. Pauciulo, William C. Nichols, Anna R. Hemnes, Atul Malhotra, Nick H. Kim, Jason X-J Yuan, Timothy Fernandes, Kim M. Kerr, Laith Alshawabkeh, Ankit A. Desai, Andreea M. Bujor, Robert Lafyatis, Jeramie D. Waltrous, Tao Long, Susan Cheng, Stephen Y. Chan, Mihit Jain University of California San Diego. Peking University.

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Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups

Brianna M. Liberio, Gregory Seedorf, Danielle E. Soranno, John R. Montford, Sarah G. Faubel, Andres Hernandez, Steven H. Abman, Jason GienIndiana University School of Medicine. University of Colorado School of Medicine. Rocky Mountain Regional VA Medical Center. United States Pediatric ResearchPediatr Res 2023; DOI: 10.1038/s41390-023-02625-y AbstractBackground: Acute kidney injury (AKI) is common in sick neonates and associated

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Plasma mid-regional proadrenomedullin level in children with pulmonary hypertension associated with CHD

Shimaa A. Elesawy, Hesham A. El-Serogy, Esraa A. Sorour, Amr M. Zoairar Elsalam General Hospital and Ministry of Health. Tanta University. Egypt Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123000471 AbstractAdrenomedullin has been shown to inhibit proliferation in pulmonary artery smooth muscle cells and to alleviate pulmonary artery collagen accumulation in pulmonary hypertension. We aimed to

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Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival

Guillermo Torres, Jun Yang, Megan Griffiths, Stephanie Brandal, Rachel Damico, Dhananjay Vaidya, Catherine E. Simpson, Michael W. Pauciulo, William C. Nichols, David D. Ivy, Eric D. Austin, Paul M. Hassoun, Allen D. EverettJohns Hopkins University. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center. Children’s Hospital Colorado. Vanderbilt University Medical Center.United States Pulmonary

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The Role of the Interleukin-1 Family in Complications of Prematurity

Elys A. Green, Steven P. Garrick, Briana Peterson, Philip J. Berger, Robert Galinsky, Rod W. Hunt, Steven X. Cho, Jane E. Bourke, Marcel F. Nold, Claudia A. Nold-PetryHudson Institute of Medical Research. Monash University. Monash Children’s Hospital. Australia International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24032795 AbstractPreterm birth is a major contributor

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Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model

R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R.

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Multiomics endotyping of preterm infants with bronchopulmonary dysplasia and pulmonary hypertension-A pilot study

Roopa Siddaiah, Christiana Oji‐Mmuo, Vincent P. R. Aluquin, Yuka Imamura Kawasawa, Ann Donnelly, Dustin Rousselle, Nathalie Fuentes, Eric D. Austin, Patricia SilveyraPenn State Health and Children’s Hospital. Indiana University School of Public Health. Vanderbilt University.United States Pulmonary CirculationPulm Circ 2023; 13: DOI: 10.1002/pul2.12232 Abstract Pulmonary hypertension associated with bronchopulmonary dysplasia is a severe complication of preterm

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Lactylation: novel epigenetic regulatory and therapeutic opportunities

Haoqin Fan, Fan Yang, Zhenghui Xiao, Haiyan Luo, Huaiyang Chen, Zhi Chen, Qiming Liu, Yunbin XiaoHengyang Medical School and University of South China. Hunan Children’s Hospital. Second Xiangya Hospital, Central South University. China American Journal of Physiology Endocrinology and MetabolismAm J Physiol Endocrinol Metab 2023; 324: E330-E338DOI: 10.1152/ajpendo.00159.2022 AbstractLactate, which is an end product of glycolysis,

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Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates

Faeq Almudares, Joseph Hagan, Xinpu Chen, Sridevi Devaraj, Bhagavatula Moorthy, Krithika LingappanBaylor College of Medicine. Children’s Hospital of Philadelphia.United States Pediatric PulmonologyPediatr Pulmonol 2023; 58: 271-278DOI: 10.1002/ppul.26197 AbstractGrowth and differentiation factor 15 (GDF15) is a stress-responsive cytokine, and its expression increases during inflammation, hyperoxia, and senescence. Significantly, GDF15 is secreted by the placenta, and maternal levels

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