Aisling Smith, Orla Franklin Mrcpch, Naomi McCallion, Fionnuala Breathnach, Afif El-Khuffash
The Rotunda Hospital. Our Lady’s Children’s Hospital Crumlin. The Royal College of Surgeons in Ireland.
Ireland
Journal of Pediatrics
J Pediatr 2023;
DOI: 10.1016/j.jpeds.2023.113645
Abstract
Objective: To assess serial myocardial performance and pulmonary vascular resistance (PVR) in infants of mothers with gestational diabetes mellitus (GDM) over the first year of age.
Study design: This was a prospective, observational study. Echocardiography was performed at birth, 6 months ,and 1 year of age. Pulmonary artery acceleration time (PAAT) and left ventricular (LV) eccentricity index (LVEI) provided surrogate measurements of PVR. Biventricular function was assessed by tissue Doppler imaging and deformation analysis.
Results: Fifty infants of mothers with GDM were compared with 50 controls with no difference in gestation (38.9 ± 0.8 vs 39.3 ± 0.9 weeks, p = 0.05) or birthweight (3.55 ± 0.49 vs 3.56 ± 0.41 Kg, p=0.95). At one year of age PAAT was lower (70 ± 11 vs 79 ± 10, p=0.01) in the GDM group. LV global longitudinal strain (24.7 ± 1.9 vs 28.8 ± 1.8 %, p<0.01), LV systolic strain rate (1.8 ± 0.2 vs 2.1 ± 0.3 1/s, p<0.01), and RV free wall strain (31.1 ± 4.8 vs 34.6 ± 3.9 %, p<0.01) were lower in the GDM cohort at 1 year of age (all p values adjusted for gestation, mode of delivery and maternal BMI).
Conclusion: Our findings demonstrate higher indices of pulmonary vascular resistance and lower biventricular function in infants of mothers with GDM compared with controls at each time point assessed in this study over the first year of age.
Category
Environmental Factors Associated with Pulmonary Vascular Disease
Right Heart Dysfunction Associated with Pulmonary Vascular Disease
Diagnostic Testing for Pulmonary Vascular Disease. Non-invasive Testing
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes