Lindsay M. Forbes, Natalie Bauer, AritraBhadra, Stefan Gräf, GustavoA.Heresi, Rachel K. Hopper, Harm J. Bogaard, Gaurav Choudhary, Kara N. Goss, Arun Jose, Yunhye Kim, Timothy Klouda, Tim Lahm, Allan Lawrie, Peter J. Leary, Jane A. Leopold, Suellen D. Oliveira, Christopher J. Rhodes, Duncan J. Stewart, Rebecca R. Vanderpool, Sasha Z. Prisco, Ruslan Rafikov, Ke Yuan, Alexsandra Zimmer, Anna R. Hemnes, Vinicio A. de Jesus Perez, Martin R. Wilkins
University of Colorado. University of South Alabama. Amsterdam UMC. Warren Alpert Medical School of Brown University. Rhode Island and Miriam Hospitals. Providence VA Medical Center. University of Texas Southwestern Medical Center. University of Cambridge. Cleveland Clinic. Stanford University School of Medicine. University of Cincinnati. Boston Children’s Hospital. National Jewish Health. Rocky Mountain Regional VA Medical Center. Imperial College London. University of Washington. Brigham and Women’s Hospital and Harvard Medical School. University of Illinois at Chicago. University of Minnesota. Indiana University. University of Ottawa. Ohio State University. Brown University. Vanderbilt University Medical Center.
United States and United Kingdom
Pulmonary Circulation
Pulm Circ 2025; 15:
DOI: 10.1002/pul2.70027
Abstract
Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.
Category
Precision Care for Pulmonary Vascular Disease
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes