Rachel K. Hopper, Georg Hansmann, Seth A. Hollander, Anne I. Dipchand, Oscar van der Have, Colleen Iler, Cynthia Herrington, Erika B. Rosenzweig, Juan C. Alejos, Karin Tran-Lundmark, on behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative & Resuscitation; Council on Clinical Cardiology; and Council on Cardiovascular Stroke Nursing
Lucille Packard Children’s Hospital and Stanford University. University Hospital Erlangen. Hospital for Sick Children and University of Toronto. Lund University and Skane University Hospital. Children’s National Hospital. Children’s Hospital Los Angeles. Westchester Medical Center Network and New York Medical College. University of California Los Angeles Mattel Children’s Hospital.
United States, Germany, Canada and Sweden
Circulation Heart Failure
Circ Heart Fail 2024;
DOI: 10.1161/HHF.0000000000000086
Abstract
Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased afterload and is an important consideration for heart transplant eligibility. However, the epidemiology, pathophysiology, optimal diagnostic and treatment approaches, and thresholds for pulmonary vascular resistance in pulmonary hypertension associated with left heart disease remain unclear because of lack of evidence, particularly in pediatrics. The result is heterogeneity with respect to hemodynamic assessment, use of pulmonary vasodilator therapies, and heart transplant listing. This scientific statement aims to synthesize the available data and highlight areas of general consensus as well as important knowledge gaps.
Category
Class II. Pulmonary Hypertension Associated with Left Ventricular Systolic or Diastolic Dysfunction
Class II. Pulmonary Hypertension Associated with Valvular Disease of the Left Side of the Heart
Review Articles Concerning Pulmonary Vascular Disease
Consensus Guidelines for Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes