Sebastian G. Michel, Maja Hanuna, Joseph Pattathu, Jelena Pabst von Ohain, Christian Schneider, Theresa Kauke, Nikolaus Kneidinger, Juergen Behr, Katrin Milger, Juergen Barton, Tobias Veit, Christine Kamla, Christoph Mueller, Robert Dzieciol, Lauren Christen, Michael Irlbeck, Roland Tomasi, Jan Abicht, Patrick Scheiermann, Matthias Feuerecker, Robert Dalla-Pozza, Marcus Fischer, Andre Jakob, Matthias Hermann, Nikolaus Haas, Christian Hagl, Jürgen Hörer
Ludwig Maximilian University Munich. Technical University of Munich. German Center for Lung Research. German Center for Cardiovascular Research.
Germany
Frontiers in Transplantation
Front Transplant 2023; 2:
DOI: 10.3389/frtra.2023.1197906
Abstract
Pulmonary hypertension (PH) is a known and life limiting complication of preterm born young adults with bronchopulmonary dysplasia (BPD), ultimately leading to progressive right ventricular (RV) failure. Prognosis remains poor, especially in patients unresponsive to modern vasoactive pharmacotherapy. Therefore, lung transplantation presents the treatment of choice to avert cardiac failure. With limited donor organ availability and long waiting times, the implantation of a paracorporeal lung assist device (PLAD) is a way to bridge the patient as an alternative to veno-arterial ECMO. Herein, we present the case of a prematurely born 23-year-old female, who developed severe PH due to BPD and consequently experienced therapy refractory RV failure. Urgent PLAD implantation was performed and the patient successfully underwent double-lung transplantation after 215 days of PLAD support. No major PLAD-associated complications occurred and full recovery of RV function could be observed after double-lung transplantation.
Category
Class III. Pulmonary Hypertension Associated with Lung Disease
Surgical and Catheter-mediated Interventions for Pulmonary Vascular Disease
Lung Transplantation for Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes