A. Dushani, C. U. Ranasinghe, T. M. Parinda B. Tennakoon, Margaret A. Schwarz
Boston Children’s Hospital and Harvard Medical School. Indiana University School of Medicine.
United States
Cells
Cells 2024; 13:
DOI: 10.3390/cells13030244
Abstract
Pulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations that contribute to the molecular and morphological changes of PH in conjunction with current animal models for studying vascular remodeling in PH will be examined. The status quo of epigenetic targeting for treating vascular remodeling in different PH subtypes will be dissected, while parallel epigenetic threads between pulmonary hypertension and pathogenic cancer provide insight into future therapeutic PH opportunities.
Category
Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease
Genetic Factors Associated with Pulmonary Vascular Disease
Environmental Factors Associated with Pulmonary Vascular Disease
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes