Ryan J. Carpenter, Nina Srdanovic, Karen Rychlik, Shawn K. Sen, Nicholas F. M. Porta, Aaron E. Hamvas, Karna Murthy, Amanda L. Hauck
Lurie Children’s Hospital of Chicago and Northwestern University.
United States
Journal of Perinatology
J Perinatol 2022; 42: 788-795
DOI: 10.1038/s41372-022-01386-6
Abstract
Objective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants with Type I severe bronchopulmonary dysplasia (sBPD).
Study design: We measured the pulmonary artery acceleration time indexed to the right ventricular ejection time (PAAT/RVET) and right ventricular free wall longitudinal strain (RVFWLS) at 34-41 weeks’ postmenstrual age. Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks’ postmenstrual age to room-air or discharge with oxygen (≤0.5 L/min).
Result: For 102 infants, the mean PAAT/RVET and RVFWLS were 0.27 ± 0.06 and -22.63 ± 4.23%. An abnormal measurement was associated with an increased time to achieve the outcome (PAAT/RVET: 51v24, p < 0.0001; RVFWLS; 62v38, p = 0.0006). A normal PAAT/RVET was independently associated with a shorter time to outcome (aHR = 2.04, 1.11-3.76, p = 0.02).
Conclusion: The PAAT/RVET may aid in anticipating timing of discharge in patients with type I severe BPD.
Category
Class III. Pulmonary Hypertension Associated with Lung Disease
Diagnostic Testing for Pulmonary Vascular Disease. Non-invasive Testing
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: No