Shi-Cheng Zeng, Xian-Lu Zhou, Ling-Ling Xiang, Zi-Yu Hua
Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, and Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases
China
Chinese Journal of Contemporary Pediatrics
Zhongguo Dang Dai Er Ke Za Zhi 2026; 28: 446-451
DOI: 10.7499/j.issn.1008-8830.2508024
Abstract
Objectives: To study the association between adverse outcomes during hospitalization and early postnatal weight changes in term appropriate-for-gestational-age (AGA) infants with early-onset sepsis (EOS).
Methods: A retrospective study was conducted on clinical data of term AGA infants with EOS admitted to the Children’s Hospital of Chongqing Medical University from January 2023 to September 2024. The infants were divided into a weight-gain group (weight difference > 0 kg; n=229) and a no-weight-gain group (weight difference ≤ 0 kg; n=131) based on the change in weight from birth to postnatal day 7, and the incidence of adverse outcomes during hospitalization was compared between groups.
Results: Length of hospital stay, duration of antibiotic use, and duration of mechanical ventilation in the weight-gain group were longer than those in the no-weight-gain group (P<0.05). The incidence of acute kidney injury, electrolyte imbalance, intracranial hemorrhage, patent ductus arteriosus, moderate-to-severe pulmonary arterial hypertension, and pulmonary hemorrhage was higher in the weight-gain group than in the no-weight-gain group (P<0.05). Daily net fluid balance on postnatal days 5 and 6, and cumulative net fluid balance on postnatal days 5-7, were higher in the weight-gain group than in the no-weight-gain group (P<0.05).
Conclusions: Early postnatal weight gain in term AGA infants with EOS is associated with an increased incidence of adverse outcomes during hospitalization, and weight change can serve as one of the indicators to assess neonatal fluid balance.
Category
Class I. Pulmonary Hypertension Associated with Infection
Acquired Patient Factors Associated with Pulmonary Vascular Disease
Potential Biomarkers Associated with Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
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