Carly E. Byrd, John T. Wren, Suneetha Desiraju, Patrick J. McNamara
Johns Hopkins University School of Medicine. University of Iowa Hospitals and Clinics.
United States
Journal of Perinatology
J Perinatol 2026;
DOI: 10.1038/s41372-026-02582-4
Abstract
Despite ample research in acute pulmonary hypertension in neonates with congenital diaphragmatic hernia (CDH) leading to improved survival, there is a paucity of literature on the physiology of chronic pulmonary hypertension in this population. Serial hemodynamic assessments and physiology-centric care have been shown to be safe and effective in the acute transitional and peri-operative care of these neonates and will likely be informative in the discussion of chronic pulmonary hypertension as well. Herein, we discuss the epidemiology, contributors, and proposed physiology-based phenotypes of chronic pulmonary hypertension in neonates with CDH. Further investigation is needed to contribute to our understanding and treatment of chronic pulmonary hypertension in this complex, heterogeneous population.
Category
Class III. Pulmonary Hypertension Associated with Lung Hypoplasia
Diagnostic Testing for Pulmonary Vascular Disease. Non-invasive Testing
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes