Renee S. Joosen, Gregor J. Krings, Heleen B. van der Zwaan, Nefise Karaman, Marco Guglielmo, Lucas R. Celant, Marco J. W. G€otte, Michael G. Dickinson, Michiel Voskuil, Marielle C. van de Veerdonk, Johannes M. P. J. Breur
University Medical Center Utrecht. Amsterdam University Medical Center and University of Amsterdam.
Netherlands
Journal of Thoracic and Cardiovascular Surgery Open
JTCVS Open 2025; 28: 459-468
DOI: 10.1016/j.xjon.2025.08.013
Abstract
Background: Right ventricular (RV) function is an independent predictor of prognosis in congenital heart disease (CHD), but RV adaptation to chronic pressure and/or volume overload is understudied. This study aimed to assess adaptation to chronic RV pressure and/or volume overload in CHD patients using pressure-volume (PV) loop analysis.
Methods: This retrospective study included CHD patients with a subpulmonary morphologic right ventricle and biventricular circulation who underwent right heart catheterization (RHC) and cardiac magnetic resonance (CMR) imaging within 12 months prior to RHC at the University Medical Center Utrecht between August 2013 and November 2024. RV volumes, function, pressures and wall tension were obtained. RV afterload (arterial elastance [Ea]), contractility (end-systolic elastance [Ees]), RV-pulmonary artery (PA) coupling (Ees/Ea), and diastolic stiffness (end-diastolic elastance [Eed]) were evaluated using PV loop analysis.
Results: Forty-five patients (67% male; median age, 14 [interquartile range, 9-17] years; 18 with pressure overload, 7 with volume overload, 20 with combined overload) were included. Pressure and combined overload led to a twofold increase in Ea, increased Ees, and increased Eed compared to volume overload (all P < .05), while volume and combined overload increased end-diastolic volumes (P = .010). RV-PA coupling, wall tension, and CMR-derived mass, function, and strain were similar across groups.
Conclusions: Despite similar RV function on conventional imaging, PV analysis revealed distinct RV adaptation patterns for RV pressure and/or volume overload in CHD, suggesting potential for RV overload-specific treatments.
Category
Class I. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease
Heart Dysfunction Associated with Pulmonary Vascular Disease (Right)
Diagnostic Testing for Pulmonary Vascular Disease. Invasive Testing
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes