Claudia Mickael, Jane C. Kabwe, Dara Fonseca Balladares, Annika S. Bai, Kevin Nolan, Michael H. Lee, Rahul Kumar, Joan F. Hilton, Joseph Phiri, Taonga Musonda, Katie Tuscan, Linda Sanders, Kurt R. Stenmark, Paul W. Buehler, Edford Sinkala, David C. Irwin, Sula Mazimba, Brian B. Graham
University of Colorado Anschutz Medical Campus. National Heart Hospital Lusaka and Morningstar Clinic Lusaka. niversity of California San Francisco and Zuckerberg San Francisco General Hospital. University Teaching Hospital Lusaka. University of Maryland Baltimore School of Medicine. AdventHealth. University of Virginia.
United States and Zambia
Pulmonary Circulation
Pulm Circ 2025; 15:
DOI: 10.1002/pul2.70230
Abstract
Schistosomiasis and sickle cell disease (SCD) both cause pulmonary hypertension (PH). We identified a subject with sickle cell trait and hepatosplenic schistosomiasis, who on right heart catheterization had PH, but due to high cardiac output. In a pre-clinical model, we found SCD mice were protected from developing schistosomiasis-induced PH.
Category
Class V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders
Class I. Pulmonary Hypertension Associated with Infection
Animal Models of Pulmonary Vascular Disease and Therapy
Age Focus: Adult Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes