Rebecca J. Kameny, Rachel K. Hopper
Stanford University.
United States
Clinics in Perinatology
Clin Perinatol 2025; 52: 633-653
DOI: 10.1016/j.clp.2025.08.002
Abstract
Pulmonary hypertension (PH) in the neonatal intensive care unit represents a complex and diverse spectrum of conditions, from transient persistent pulmonary hypertension of the newborn to chronic PH associated with bronchopulmonary dysplasia, congenital heart disease, and other conditions, and can cause significant morbidity and mortality. Proper classification, timely diagnosis using echocardiography and imaging, and tailored therapy are essential. A multidisciplinary approach is critical, particularly for infants with unclear or genetic causes. This article provides a thorough overview of the current classification schema of pulmonary hypertension, underlying pathophysiology, diagnostic work-up, treatment options, and long-term prognosis.
Category
Class I. Persistent Pulmonary Hypertension of the Newborn
Class III. Pulmonary Hypertension Associated with Lung Disease
Class III. Pulmonary Hypertension Associated with Lung Hypoplasia
Class III. Pulmonary Hypertension Associated with Developmental Diseases of the Lung
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: No