Kylie Holden, Devin Saljuud, Kevin Johnson, Matthew T. Harting
McGovern Medical School at the University of Texas Health Science Center. Vanderbilt University.
United States
Seminars in Fetal and Neonatal Medicine
Semin Fetal Neonatal Med 2025;
DOI: 10.1016/j.siny.2025.101659
Abstract
Infants with congenital diaphragmatic hernia (CDH) face severe pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction, making it one of the most challenging neonatal conditions to manage. Advances in extracorporeal life support (ECLS) have the potential to significantly improve outcomes for the most severe infants with CDH. There has been significant evolution in indications, technology, and clinical strategies which have enhanced its role and improved early stabilization, management, and outcomes. While ECLS remains the foundational management strategy for the most challenging and highest-risk CDH patients, there remains no standard, evidence-based, or widely adopted approach, with variability across centers and ongoing equipoise regarding the optimal timing and criteria, highlighting the need for the development of evidence, further understanding, and refined approaches in CDH. In this review, we highlight recent advances and progressive approaches to ECLS in CDH.
Category
Class III. Pulmonary Hypertension Associated with Lung Hypoplasia
Surgical and Catheter-mediated Interventions for Pulmonary Vascular Disease
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: No