Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Ting Huang, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao, Qiming Liu, Yunbin Xiao
Affiliated Nanhua Hospital and University of South China. Affiliated Children’s Hospital of Xiangya School of Medicine and Central South University (Hunan Children’s Hospital). Johns Hopkins School of Medicine.
China and Uhited States
Frontiers in Medicine
Front Med 2025; 12:
DOI: 10.3389/fmed.2025.1607638
Abstract
Background: Pulmonary arterial hypertension is a severe and life-threatening disease characterized by a progressive increase in pulmonary vascular resistance. Catheter-based pulmonary artery denervation (PADN) has been conducted in pulmonary arterial hypertension patients; however, if stereotactic body radiotherapy (SBRT) can become a new non-invasive way to conduct, PADN has not been elucidated.
Methods: A total of 12 healthy male New Zealand rabbits were digitally marked on their foreheads and randomly divided into the control group (n = 6) and SBRT group (n = 6) at a ratio of 1:1 using computer-generated random numbers. In the SBRT group, rabbits were treated with a single dose of 15 Grey and then bred for a minimum of 3 months. The rabbit models of acute thromboembolic pulmonary arterial hypertension (ATEPAH) were established by injecting autologous blood clots into the femoral vein. Right ventricular function and hemodynamics were assessed by echocardiography and right heart catheterization. Pulmonary artery sympathetic nerves were evaluated by pathological staining.
Results: The SBRT procedure was successfully performed in all six rabbits. Compared to the control group, SBRT-PADN reduced pulmonary artery systolic pressure and mean pulmonary artery pressure in ATEPAH rabbits. Meanwhile, SBRT-PADN could attenuate pulmonary artery dilatation in ATEPAH rabbits. Histological examination revealed evident structural damages in sympathetic nerves of SBRT-PADN animals, including vacuolization, nuclear pyknosis, and digestion chambers. No adverse events had been observed, and sparing of pulmonary artery of the intima and media was detected up to 90 days post-procedure.
Conclusion: SBRT could destroy sympathetic nerves around pulmonary artery locally, which may represent a novel option for performing PADN. In addition, this study provided its short-term effectiveness and safety.
Category
Animal Models of Pulmonary Vascular Disease and Therapy
Class IV. Pulmonary Hypertension Associated with Thromboembolic Disease
Medical Therapy. Efficacy or Lack of Efficacy
Medical Therapy. Adverse Effects or Lack of Adverse Effects
Pulmonary Vascular Pathology
Age Focus: No Age-Related Focus
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes