John Slaughter, Jeremy Sites, Hubert Ballard, John Bauer, Aric Schadler, Nicholas Severyn
University of Kentucky College of Medicine.
United States
Frontiers in Pediatrics
Front Pediatr 2025; 13:
DOI: 10.3389/fped.2025.1586985
Abstract
Introduction: Neonatal hypoxic respiratory failure is commonly assessed with the oxygenation index (OI) to determine severity and guide ECMO initiation. Calculation of the OI requires arterial blood sampling which can be difficult to obtain. A non-invasive alternative, the oxygen saturation index (OSI), has shown promise, but its utility in ECMO determination is not well-described. We aimed to evaluate the correlation between the OI and OSI in neonates requiring ECMO.
Methods: We pursued a retrospective chart review of 64 neonatal ECMO patients at Kentucky Children’s Hospital (2012-2022) and analyzed OI and OSI values in the 12 h preceding ECMO initiation.
Results: A moderate correlation was observed between the OI and OSI. An OSI >17.41 predicted ECMO initiation, and OI can be estimated with the equation: OI = 1.978(OSI)-6.743.
Conclusion: These findings suggest OSI may be a useful adjunct to OI for assessing neonatal respiratory failure and could be beneficial when arterial sampling is impractical.
Category
Class I. Persistent Pulmonary Hypertension of the Newborn
Diagnostic Testing for Pulmonary Vascular Disease. Non-invasive Testing
Surgical and Catheter-mediated Interventions for Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes